Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus

Patients with diabetes mellitus and definite autonomic and peripheral neuropathy were randomized to receive quinapril or no treatment for 2 years.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Diabetic Autonomic Neuropathy Diabetes Complications Diabetes Mellitus Diabetic Neuropathies Endocrine System Diseases Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Diabetes mellitus with both autonomic and peripheral neuropathy

Exclusion criteria

Hypertension, coronary heart disease

Treatment and study plan

Quinapril

Drug

Primary outcomes

Changes in R-R variation during deep breathing

Time frame: 2 years
Changes in response to Valsalva maneuver

Time frame: 2 years
Changes in 30:15 ratio

Time frame: 2 years
Changes in blood pressure response to standing

Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Aristotle University Of Thessaloniki

Other

Registry information

Official study title

Efficacy of Administration of Angiotensin Converting Enzyme Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus

Important dates

Study start: 1999
Primary completion: 2001
First posted: Jan 26, 2017
Registry last updated: Jan 26, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed