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OpenTrials
Completed

NCT Number: NCT04062175

Efficacy of Adding Azithromycin to Cephalosporin Before Cesarean Delivery

efficacy of adding azithromycin to cephalosporin before cesarean delivery

Completed

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Key information

Conditions

Wound Sepsis

Age range

17 year–39 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

Ain Shams maternity hospital

Cairo, Egypt

About this study

efficacy of adding azithromycin to cephalosporin for the prophylaxis against infectious morbidity following cesarean delivery in high risk women

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age between 17 and 39 years
  • gestaional age between 37 to 42 weeks
  • elective cesarean delivery
  • obese women

Exclusion criteria

  • diabetic women on corticosteroids
  • intraopertaive complication in previous section
  • history of septic woun
  • prelabour rupture of membrane >12 hours

Treatment and study plan

cephalosporin

Drug

72 women will receive single antibiotic chemotherapy(Cefazolin) 2 gm iv within 30 minutes before skin incision

Azithromycin Tablets

Drug

72 women will receive combined antibiotic chemotherapy azithromycin(Azrolid) 1 gm single oral dose 2 hours before cesarean delivery +cephalosporin(Cefazolin) 2 gm iv within 30 minutes before skin incision

Primary outcomes

  1. % of women with wound infection

    Time frame: after 14 days post cesarean delivery

    superficial and deep surgical site wound infection will be looked for by laboratory confirmation

Secondary outcomes

  1. % of women with postpartum endometritis

    Time frame: after 14 days post cesarean delivery

    fever, abdominal pain , uterine tenderness will be looked for

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Efficacy of Adding Azithromycin to Cephalosporin for the Prophylaxis Against Infectious Morbidity Following Cesarean Delivery in High Risk Women

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Aug 20, 2019
Registry last updated
Aug 20, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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