Skip to main content
OpenTrials
Completed

NCT Number: NCT06771388

Efficacy Evaluation of Avance QQ Collagen for Skin Beautification

To assess Avance QQ Collagen product on skin condition improvement

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Skin Condition Liposomal Encapsulation Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chia Nan University of Pharmacy & Science

Pingtung City, 928, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy male or female adults, age above 18 years old;
  • The grade of crow's feet above 2 (Han et al. Sci Rep 13, 18903 (2023));
  • Commitment not to use products having activity comparable with that of the product to be tested during the study period;
  • Free of any dermatological or systemic disorder that would interfere with results.

Exclusion criteria

  • Subject with obvious skin surface damage;
  • Subject who had oral or topical medication which may affect skin condition within 1 month;
  • Subject who is a vegetarian or likely to be acutely allergic to the listed ingredients in the product;
  • Female who is pregnant, nursing or planning to become pregnant during the course of the study;
  • Received facial laser therapy, chemical peeling in the past 2 months.

Treatment and study plan

Liposomal collagen drink

Dietary Supplement

consume 50 g liquid drink daily for 8 consecutive weeks

Other names: Avance QQ Collagen

Non-liposomal collagen drink

Dietary Supplement

consume 50 g liquid drink daily for 8 consecutive weeks

Placebo drink

Dietary Supplement

consume 50 g liquid drink daily for 8 consecutive weeks

Primary outcomes

  1. The change of skin collagen density

    Time frame: Change from Baseline skin collagen density at 8 weeks

    DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units

  2. The change of skin wrinkles

    Time frame: Change from Baseline skin wrinkles at 8 weeks

    VISIA Complexion Analysis was utilized to measure skin wrinkles. Units: the amount of detectable wrinkles

  3. The change of skin elasticity

    Time frame: Change from Baseline skin elasticity at 8 weeks

    Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units

Secondary outcomes

  1. The change of wrinkles around the eyes

    Time frame: Change from Baseline wrinkles around the eyes at 8 weeks

    VISIA Complexion Analysis was utilized to measure wrinkles around the eyes. Units: the amount of detectable wrinkles

  2. The change of skin hydration

    Time frame: Change from Baseline skin hydration at 8 weeks

    Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120.

  3. The change of skin lightness

    Time frame: Change from Baseline skin lightness at 8 weeks

    Chroma Meter MM500 was utilized to measure face skin lightness. Units: L* index

  4. The change of skin tone

    Time frame: Change from Baseline skin tone at 8 weeks

    Chroma Meter MM500 was utilized to measure face skin color. Units: Individual Typology Angle (ITA°)

Other outcomes

  1. The change of self-assessment skin condition

    Time frame: Change from Baseline skin condition at 8 weeks

    A self-assessment questionnaire was collected and evaluate skin condition.

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 13, 2025
Registry last updated
Apr 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.