Efficacy and Safety Trial With S 44819 After Recent Ischemic Cerebral Event

Inclusion criteria

• Patients aged between 18 and 85 years (both inclusive)
• Acute ischemic stroke that occured between 72 hours (3 days) and 192 hours (8 days) (both inclusive) before inclusion

Exclusion criteria

• Any non-selection criteria, which could have occurred after the selection visit
• Positive urinary or blood pregnancy test (for female patients of child bearing potential)
• Any clinically significant findings from the local laboratory test likely to interfere with the ability to participate in the study and / or with the study outcome
• Severe renal impairment detected in the local laboratory test
• Severe hepatic impairment or liver enzymes abnormalities found in the local laboratory test
• Stroke due to cerebral venous thrombosis
• Brain MRI showing a severe microangiopathy
• Brain imaging showing an acute haemorrhagic stroke or a symptomatic haemorrhagic transformation of the brain infarct
• Qualifying ischemic cerebral event older than 192 hours at inclusion
• Any clinically relevant abnormalities detected during the examinations likely to interfere with study procedures or study outcome,
• Repeated prolongation of ECG QTcF
• Patient or authorised representative refusing to attend study visits or to take part in the study