Efficacy and Safety Study of Total Flavonoids of Propolis Dropping Pill to Treat Angina Pectoris

Inclusion criteria

• Class I, Class II and Class III stable angina pectoris, angina attack more than 3 times one week;
• Qi deficiency and blood stasis syndrome of Traditional Chinese Medicine;
• In resting electrocardiogram, ST-segment deviation≥0.05mv and/or T-wave inversion≥0.2mv in the leads R-wave is predominant during non-attack period, or ST-segment deviation≥0.1mv and/or T-wave inversion≥0.2mv in the leads R-wave is predominant during angina attack;
• Total exercise time of treadmill exercise test≥3 minutes.The discontinuance standard should be reached. And the difference of total exercise time between before and after run in period should ≤15%;
• Other confirmed diagnostic evidence of coronary heart disease, such as definite history of old myocardial infarction, or incomplete revascularization one year after coronary intervention therapy(residual luminal stenosis≥50%), or coronary angiography evidence(at least single vessel disease and luminal stenosis≥50%), or nuclein examination evidence, or computer tomography angiography evidence;
• Signed the informed consent form.

Exclusion criteria

• Chest pain caused by acute myocardial infarction(AMI), Class IV/serious angina pectoris, psychosis, serious neurosis, climacteric syndrome, hyperthyroidism, Cervical Spondylosis, gallbladder- heart syndrome, gastroesophageal reflux, hiatus hernia, aortic dissection, aortic valve disease;
• Not well controlled hypertension(systolic pressure≥160mmHg，diastolic pressure≥100mmHg), serious cardiopulmonary insufficiency, serious arrhythmia(rapid atrial fibrillation, atrial flutter, paroxysmal ventricular tachycardia, etc);
• Serious diseases of heart, lung, liver, kidney and blood;
• Allergic constitution or allergic to the components of total Flavonoids of Propolis dropping pill;
• Women during pregnancy or lactation;
• Received any major operation within 4 weeks;
• Have been in other clinical trials within 30 days;
• Using but can not withdraw anti-angina medicine as long acting nitrates;
• Not well controlled hyperglycemia;
• Not fit for this trial judged by investigator.