Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women

Patients will be included by investigators or coinvestigateurs, the day of consultation in the emergency adult department in Clermont-Ferrand city.

The diagnosis of acute uncomplicated pyelonephritis is established in the emergency department based on the clinical, laboratory and imaging criteria.

Clinical, biological and radiological data will gathered during this consultation :

• Clinical data: flank pain, fever, urinary symptoms,
• Biological data: urine dipstick (BU No. 1), cytobacteriological urinary (ECBU No. 1), blood prélèvements (Blood count, creatinine, CRP)
• Imagery: renal and bladder ultrasound. During the next consultations in the emergency department, respectively on day 3 (J3) of treatment and on day 9 (J9), urine tests (urinary dipsticks [BU No. 2 and No. 3] and cytobacteriological urinary [ECBU No. 2 and No. 3] will be realised. The clinical and biological management of patient will be performed by the same department to ensure a better comparability of biological results and a centralized real-time clinical data.

Patient follow-up will end with a phone call on day 37 (J37), and the rate of clinical relapses and / or biological occurred between day 9 and day 37.

Inclusion criteria

• Women between 18 and 65 years old
• Diagnosis of Acute Uncomplicated Pyelonephritis
• Patient obliged to participate in the French national health and pensions system.
• Patient who have read, understood and signed the consent

Exclusion criteria

• Women who are pregnant
• Men
• One of these risk factor who define a complicated pyelonephritis:

Medical history of uro-nephrology problem Nephropathy Obstructive Uropathy Vesicoureteral reflux Post mictinal residue > 100mL Urinary fistula Catheter vesicle and urethral Kidney transplantation Immunodeficiency Diabetes

• Recurrent pyelonephritis
• Allergy of betalactam or cephalosporin
• History of hypersensitivity reactions to antibiotic medications
• Patient in terminal care
• Trouble of cognitive function
• Patient deprive of judicial or administrative freedom
• Patient participating to another trial
• Refusal to participate to the trial