Efficacy and Safety Study of Aripiprazole to Treat Schizophrenia

Inclusion criteria

Inclusion criteria

for screening

• Schizophrenia or Acute schizophrenia-like psychotic disorder(ICD 10)
• PANSS total of no less than 60
• Age: 18-65; male or female
• Informed consent from the legal guardians of the patients Inclusion criteria after washout

1.PANSS total of no less than 60 2.3-7days washout with placebo is required after discontinuation of other oral antipsychotics; No washout is needed for patients who had never taken any antipsychotics before; In cases that patients's condition is deemed clinically deteriorating and immediate treatment is needed, patients with less than 3 days' placebo washout could be randomized after notifying the sponsor 3.No serious function impairment in heart, liver or kidney.

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Exclusion criteria

For screening

• Tendency or history of suicide
• Patients with extreme agitation, violent attacking behavior towards people and those who can hardly comply with treatment
• Diagnosis of other mental diseases besides Schizophrenia
• Diabetes or other serious unstable diseases or the following neurological diseases, migraine, epilepsy, Parkinson's disease, Alzheimer's disease, multiple sclerosis, stroke and TIA etc
• Patients who take Fluoxetine in the past 1-month before screening
• Patients who had participated any other clinical trial in the past 1-month before screening
• History of alcohol or drug abuse or dependence
• Pregnancy or breast-feeding
• Patients who have had gastrointestinal operations that could affect drug absorption.
• Allergy to Risperidone or Aripiprazole or hypersensitiveness to any drug
• Patients who discontinued long-acting antipsychotics less than one treatment cycle before screening
• Refractory schizophrenia patients who did not respond to treatments of two different type antipsychotics with adequate dose and course, or patients who did not respond to Clozapine
• Patients who had Electroconvulsive Therapy (ECT) in the past 6 months After washout

• Diagnosis of other mental diseases besides schizophrenia during the washout period 2. Significant abnormal ECG or laboratory examination results (ALT,AST>1.5 times of higher limit of normal range), not suitable to be enrolled based on the investigator's discretion.

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