Efficacy and Safety of TTM in Adults With ECPR.

Inclusion criteria

• Patients aged ≥18 and ≤60 years;
• Patients with in-hospital and out-of-hospital cardiac arrest of any initial rhythm;
• Patients who have received cardiopulmonary resuscitation for >10 minutes without achieving return of spontaneous circulation;
• Patients with a reversible cause of cardiac arrest (acute myocardial infarction, pulmonary embolism, all initial defibrillatable rhythm, cardiomyopathy);

Exclusion criteria

• cardiac arrest due to trauma;
• pregnant and lactating women;
• unwitnessed cardiac arrest;
• out-of-hospital cardiac arrest not receiving CPR within 5 minutes;
• > 60 minutes from the onset of cardiac arrest to the initiation of extracorporeal cardiopulmonary resuscitation;
• achievement of return of spontaneous circulation before the start of external cardiopulmonary resuscitation;
• intracranial hemorrhage or suspected intracranial hemorrhage;
• pre-existing neurologic impairment (CPC ≥ 3) prior to the onset of cardiac arrest;
• those with end-stage heart failure;
• those with new-onset cerebral hemorrhage or cerebral infarction;
• other vascular conditions such as severe plaque in bilateral femoral arteries that cause difficulty in tube placement;
• patients with combined malignant tumors;
• other serious diseases with a life expectancy of <1 year;
• refusal to perform extracorporeal cardiopulmonary resuscitation and/or target temperature administrators.
• Temperature <30°C.