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NCT Number: NCT06931457

Efficacy and Safety of Pulsed Radiofrequency Combined With Platelet Rich Plasma to Treat Idiopathic Glossopharyngeal Neuralgia (GPN)

To investigate the efficacy and safety of the application of PRF combined PRP to the for the treatment of GPN.

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Key information

Conditions

Glossopharyngeal Neuralgia Cranial Nerve Diseases Glossopharyngeal Nerve Diseases Nervous System Diseases Platelet Rich Plasma Pulsed Radiofrequency

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Beijing Tiantan Hospital

Beijing, Beijing Municipality, 100070, China

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age >18 years;
  • diagnosed with idiopathic GPN according to the third International Classification of Headache Disorders (ICHD) classification;
  • patients who failed pharmacotherapy or intolerable side effects of medication;
  • undergoing PRF for GPN;
  • at least 1 month of follow-up recordings.

Exclusion criteria

  • Patients with bilateral GPN;
  • Abnormalities in blood measurements, liver and kidney function, blood glucose, coagulation, electrocardiography or chest radiography;
  • Infection at the puncture site;
  • Previous mental illness;
  • Previous history of narcotic drug abuse;
  • Prior anticoagulant or antiplatelet therapy;
  • An implantable pulse generator;
  • Current pregnancy or breast feeding.
  • Patients with incomplete medical records (lack of baseline data or postoperative follow-up data).

Treatment and study plan

Primary outcomes

  1. Numeric rating scale (NRS) score

    Time frame: 1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure

    Numeric rating scale (NRS) score during resting was used to evaluate pain intensity before and after PRF treatment (0=no pain, 10=intolerable pain)

Secondary outcomes

  1. Barrow Neurological Institute pain scale(BNI score)

    Time frame: 1day, 3days, 1week, 2weeks, 1month, 3months, 6months, and 1year following the procedure

    BNI score during resting was used to evaluate pain relief

Study contacts

Contact information is provided by the study sponsor or research team.

Fang Luo, M.D.

CONTACT

[email protected]

+86 13611326978

Sponsors and collaborators

Lead sponsor

Beijing Tiantan Hospital

Other

Collaborators

  • China-Japan Friendship Hospital
  • The Second Hospital of Hebei Medical University

Registry information

Official study title

Efficacy and Safety of the Application of Pulsed Radiofrequency, Combined With Platelet Rich Plasma, to the Treatment of Idiopathic Glossopharyngeal Neuralgia (GPN): A Study Protocol for a Multi-Center, Prospective, Open-Label, Propensity Score Match Cohort Study

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 17, 2025
Registry last updated
Jul 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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