Efficacy and Safety of Probiotic Treatment as a Supportive Therapy in Eradication of H. Pylori

Gastroenterologists and general practitioners have increasingly more possibilities of prescribing probiotic preparations as the only or (more often) adjuvant therapy in certain indications. A significant step forward was made in the current report of the European Helicobacter Study Group ,which states that "Certain probiotics and prebiotics show promising results as an adjuvant treatment in reducing side effects". At this stage,probiotics are classified as Grade D recommendation. That is precisely why the investigators believe that clinical studies are necessary in order for such effects to be objectively proven in a clinical setting.

The investigators decided to conduct a clinical trial based on a clearly defined and sufficiently frequent indication,with a preparation of known probiotic composition that is easily available on the market, and in a real setting where such approach is bound to show both advantages and disadvantages.

Inclusion criteria

• Confirmed H. Pylori infection.
• Otherwise healthy subjects taking H. pylori eradication therapy.
• Age above 16 years.
• Male and female subjects.
• Subject who provided written informed consent prior to undergoing any study procedure.

Exclusion criteria

• Pregnancy or lactation.
• Severe diseases such as malignant diseases, severe renal/liver impairment, HIV infection etc.
• Chronic diseases such as diabetes mellitus, hypertension, epilepsy or atherosclerosis which are under treatment and well regulated are not an exclusion criterion.
• Subject who is not mentally capable of adhering to the protocol.
• Drug addiction or alcoholism.
• Any other clinical condition which, in the opinion of the attending physician, would not allow safe administration of the study medications.
• Subjects participating in any other clinical trial.