Skip to main content
OpenTrials
Completed

NCT Number: NCT07486414

Efficacy and Safety of NP-2007 on Skin Health

The objective of this study is to evaluate the efficacy and safety of Small-molecular-weight deer antler collagen (NP-2007) on skin health, including skin hydration, transepidermal water loss (TEWL), elasticity, and eye wrinkles.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Skin Aging, Dry Skin

Age range

35 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Corederm Skin Research Center

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy females between 35 and 65 years of age
  • Subjects with dry skin (Skin capacitance ≤ 49 units measured by Corneometer® CM 825)
  • Subjects with eye wrinkles (grade 3 or higher based on visual assessment scale)
  • Subjects who voluntarily signed the informed consent form after receiving a full explanation of the study
  • Subjects who are available for follow-up visits at scheduled times throughout the study period

Exclusion criteria

  • 1) Subjects with skin diseases (atopic dermatitis, psoriasis, etc.) in the test area
  • Subjects who have used skin-related medications (steroids, etc.) within 1 month
  • Subjects with a history of hypersensitivity to the test ingredients or severe food allergies
  • Pregnant or lactating women, or those planning to become pregnant
  • Subjects who have participated in other clinical trials within the past 3 months
  • Any other conditions that the investigator deems unsuitable for participation

Treatment and study plan

NP-2007

Dietary Supplement

500mg/day, once a day, take 2 tablets with water.

Placebo

Dietary Supplement

Take 2 tablets (matching NP-2007) once a day with water.

Primary outcomes

  1. Change from Baseline in Skin Hydration at 12 weeks

    Time frame: Baseline, 6 weeks, 12 weeks

    Measured using Corneometer® CM 825. The unit of measure is arbitrary units (AU) ranging from 0 to 120. Higher scores indicate improved skin moisture.

  2. Change from Baseline in Transepidermal Water Loss (TEWL) at 12 Weeks

    Time frame: Baseline, 6 weeks, 12 weeks

    Measured using Tewameter® TM 300. The unit of measure is g/m²/h. Lower values indicate improved skin barrier function.

  3. Change from Baseline in Skin Scaling at 12 Weeks

    Time frame: Baseline, 6 weeks, 12 weeks

    Evaluated using D-Squame® and image analysis. Higher values indicate more scaling (worse), lower values indicate improvement.

  4. Change from Baseline in Skin Roughness at 12 Weeks

    Time frame: Baseline, 6 weeks, 12 weeks

    Measured using Visiometer® SV 700. Assesses the texture of the skin surface. Lower values indicate smoother skin.

  5. Change from Baseline in Eye Wrinkles (Ra) at 12 Weeks

    Time frame: Baseline, 6 weeks, 12 weeks

    Quantitative analysis of eye wrinkles (crow's feet) using Visiometer® SV 700. Ra represents the average roughness in millimeters (mm). Lower values indicate improved wrinkle depth.

  6. Change from Baseline in Skin Elasticity (R2) at 12 Weeks

    Time frame: Baseline, 6 weeks, 12 weeks

    Measured using Cutometer® MPA 580. R2 represents gross elasticity (0 to 1 scale). Higher values indicate better skin elasticity.

Secondary outcomes

  1. Investigator's Visual Assessment Grade for Eye Wrinkles

    Time frame: Clinical grading of eye wrinkle severity by a dermatologist. The grade is based on a visual scale from 0 to 9 (0 = None, 9 = Very Severe). Lower grades indicate clinical improvement in wrinkle severity.

    Baseline, 6 weeks, 12 weeks Clinical grading of eye wrinkle severity by a dermatologist using a visual analog scale. The scale ranges from 0 to 9, where 0 indicates 'None' (no wrinkles) and 9 indicates 'Very Severe' wrinkles. A decrease in the score (lower values) represents a better outcome (improvement in wrinkles).

  2. Participant Subjective Questionnaire Assessment for Skin Improvement

    Time frame: Participants assess skin improvement and satisfaction through a self-report questionnaire using a 5-point Likert scale (1 = Very Dissatisfied, 5 = Very Satisfied). Higher scores indicate greater satisfaction with the product's efficacy.

    6 weeks, 12 weeks Participants' self-assessment of skin improvement using a 5-point Likert scale. The scale ranges from 1 to 5, where 1 indicates 'Very Dissatisfied' and 5 indicates 'Very Satisfied'. A higher score represents a better outcome (higher satisfaction and perceived efficacy).

Sponsors and collaborators

Lead sponsor

Hanpoong Nature Pharm Co., Ltd.

Industry

Registry information

Official study title

A 12-week, Randomized, Double-Blind, Placebo-Controlled Human Clinical Study to Evaluate the Efficacy and Safety of Small-Molecular-Weight Deer Antler Collagen (NP-2007) for Improving Skin Health

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Mar 20, 2026
Registry last updated
Mar 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.