Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

A multicenter, randomized, single-blind, active controlled, phase III clinical trial to evaluate the efficacy and safety of HUC3-637 in patients with primary open angle glaucoma or ocular hypertension

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Key information

Conditions

Primary Open Angle Glaucoma (POAG) Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

Kangbuk Samsung Hospital

Seoul, South Korea

Location status: Recruiting

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults aged 19 years and older
Participants diagnosed with POAG or OH
Have fully explained and understood the study and have voluntarily given written informed consent.

Exclusion criteria

Acute or chronic angle-closure glaucoma
Congenital glaucoma, secondary glaucoma (open-angle glaucoma)

Treatment and study plan

HUC3-637

Drug

Ophthalmic solution instilled directly into the eye (topical ocular administration)

HUC3-637-R

Drug

Ophthalmic solution instilled directly into the eye (topical ocular administration)

Primary outcomes

Mean change in diurnal IOP

Time frame: 12 week

Study contacts

Contact information is provided by the study sponsor or research team.

Rang Lee

CONTACT

[email protected]

07074926091

Sponsors and collaborators

Lead sponsor

Huons Co., Ltd.

Industry

Registry information

Official study title

A Multicenter, Randomized, Single-blind, Active Controlled, Phase III Clinical Trial to Evaluate the Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: Jan 13, 2026
Registry last updated: Jan 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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