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Completed

NCT Number: NCT03063073

Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block

The Pecs block (pectoral nerves block) is an easy and reliable superficial block inspired by the infraclavicular block approach and the intercostal abdominis plane blocks . Many additives were used in combination with local anesthetics in Pecs block to prolong the postoperative analgesia (fentanyl, dexmedetomidine).

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Key information

Conditions

Breast Cancer Female

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 3

Primary location

South EGYPT cancer institute

Asyut, 088, Egypt

About this study

60 patients scheduled for modified radical mastectomy surgery under general anesthesia. Group I (Bupivacaine group): patients underwent modified radical mastectomy were given preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine divided into 10 ml injected between the pectoralis muscles on the interfascial plane, and 20 ml injected between the Pectoralis minor muscle and the serratus muscle.Group II (Bupivacaine + Dexmedetomidine group) : preoperative ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine plus Dexmedetomidine (1 µg/kg) divided into 20 ml injected between the pectoralis muscles on the interfascial plane , and 10 ml injected between the Pectoralis minor muscle and the serratus muscle.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I - II patients
  • weight 50- 100 kg
  • age 18-60 years

Exclusion criteria

  • History of bleeding diathesis
  • Relevant drug allergy
  • Opioid dependence
  • Sepsis
  • Those with psychiatric illnesses that would interfere with perception and assessment of pain will be excluded from the study

Treatment and study plan

Dexmedetomidine Injection [Precedex]

Drug

ultrasound guided modified Pecs block with 30 mL of 0.25% bupivacaine (markyrene R sigma -Tec, Egypt) plus (1 µg/kg) Dexmedetomidine Injection [Precedex]

Other names: [Precedex]

Bupivacaine Injection [Marcaine]

Drug

ultrasound guided modified Pec's block with 30 mL of 0.25% bupivacaine divided into 10 ml injected between the pectoralis muscles and 20 ml between the Pectoralis minor muscle and the serratus muscl

Primary outcomes

  1. I.V patient controlled analgesia (PCA) morphine consumption

    Time frame: 48 hours postoperative

    the total dose of I.V patient controlled analgesia (PCA) morphine consumption in the first 48 hours postoperative

Secondary outcomes

  1. pain relief

    Time frame: 48 hour

    by visual analogue scale measurement

Other outcomes

  1. stress response

    Time frame: 24 hour

    Three Blood samples were collected from each patient for detection of cortisol & prolactin levels, the first was preoperative, the second and the third were 1h and 24 h postoperatively

Sponsors and collaborators

Lead sponsor

South Egypt Cancer Institute

Other

Registry information

Official study title

Efficacy and Safety of Dexmedetomidine Added to Modified Pectoral's Block in Patient Undergoing Breast Cancer Surgery :A Comparative Study

Acronym: pec's

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Feb 24, 2017
Registry last updated
Feb 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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