Efficacy and Safety of Cytoflavin® Used in Elderly Patients for the Prevention of Cognitive Decline After Major Surgery

Cytoflavin® (Inosine + Nicotinamide + Riboflavin + Succinic Acid) is a combination drug, which improves coronary and cerebral blood flow, activates metabolic processes in the central nervous system, restores impaired consciousness, promotes regression of neurological symptoms and improvement of cognitive functions of the brain. It has a quick awakening effect in post-anesthetic depression of consciousness. The positive effect of Cytoflavin® on cognitive function has been previously shown in patients with dyscirculatory encephalopathy and acute stroke, as well as in a population of patients during cardiac surgery in cardiopulmonary bypass and working heart. The present study aims to evaluate the opportunity of prevention of postoperative cognitive decline by administration of Cytoflavin® at a sequential regimen, starting from intravenous infusions and followed by oral intake during 1 month.

Study objectives:

• To study the efficacy of Cytoflavin® administered in elderly patients age for the prevention of cognitive decline after major surgery.
• To study the safety and tolerability of Cytoflavin® in elderly patients for after major surgery.

Inclusion criteria

• Signed informed consent
• Men and women aged 60-80 years, inclusive.
• Planned cardiac surgery, which does not assume the use of a cardiopulmonary bypass.
• Planned or delayed orthopedic surgery (hip joint endoprosthetics, osteosynthesis for fractures of the proximal third of the hip, etc.), under general or combined anesthesia.
• Legal capacity of the patient
• Absence of dementia (MoCA≥17, MMSE≥19)
• Lack of reproductive potential or
• Consent to use adequate methods of contraception

Exclusion criteria

• Hypersensitivity to any component of the study drug
• Emergency surgery
• Repeated surgery or reoperation
• Anesthesia risk ASA≥5
• Severe visual or hearing impairment which impedes the performance of neuropsychological tests
• Operation under general anesthesia in the previous 3 months
• Severe renal failure requiring replacement of renal function (dialysis)
• Severe hepatic failure (class C and above in Child-Pugh)
• Chronic obstructive pulmonary disease
• Terminal stage of other chronic incurable diseases
• Decompensated diabetes
• A history of oncological diseases, mental illness, HIV infection, syphilis, tuberculosis, alcohol or drug addiction
• The use of 5 or more units of alcohol per week in the previous 3 months
• Diagnosis of mental or neurodegenerative disease (e.g. schizophrenia, Parkinson's disease, clinically manifest depression)
• Permanent intake of psychotropic drugs (neuroleptics, tranquilizers, antidepressants)
• Course intake of nootropic drugs in the previous 3 months
• Communicative, sensory, motor, or any other deficiency that does not allow the patient to adequately assess their behavior and correctly fulfill the conditions of the study protocol.
• The presence in the history of any significant, according to the physician-researcher, condition that prevents the inclusion of the patient in the study.
• Participation in any clinical study in the previous 3 months
• Employees of the study centres and their family members.