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NCT Number: NCT06937047

Efficacy and Safety of Cold Versus Hot Snare Polypectomy for Removal of 4-10 mm Pedunculated Colorectal Polyps

This was a non-inferiority randomized controlled trial designed to compare the efficacy and safety of cold versus hot snare polypectomy for the removal of 4-10 mm pedunculated colorectal polyps. The primary outcome was delayed postpolypectomy bleeding. The secondary outcomes included immediate postpolypectomy bleeding, procedure time, en bloc resection, complete histologic resection, use of haemostatic clips and perforation rate.

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Key information

Conditions

Colorectal Polyps

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-80 years old, male and female
  • Proposed colonoscopy and colonoscopy detection of at least one 4-10 mm pedunculated colorectal polyp

Exclusion criteria

  • Contraindication to colonoscopy or polypectomy
  • Use of antiplatelet or anticoagulant drugs within 1 week before polypectomy
  • Alarming signs and symptoms of colorectal cancer (blood in stool, black stool, unexplained anaemia and weight loss, abdominal mass, positive rectal examination; or imaging and laboratory tests highly suspicious for colorectal cancer) or endoscopic manifestations of polyps highly suspicious for high-grade intraepithelial neoplasia or carcinoma
  • Comorbidity with inflammatory bowel disease, colonic polyposis, or active gastrointestinal bleeding
  • Inadequate bowel preparation
  • Pregnant or lactating women
  • Failure to sign the informed consent form
  • Patients deemed ineligible by investigators to enrol in the trial

Treatment and study plan

Cold snare polypectomy

Procedure

Cold snare polypectomy was conducted for the removal of 4-10 mm pedunculated colorectal polyps.

hot snare polypectomy

Procedure

Hot snare polypectomy was conducted for the removal of 4-10 mm pedunculated colorectal polyps.

Primary outcomes

  1. delayed postoperative bleeding

    Time frame: interviewed by telephone on days 2 and 14 after polypectomy

    bleeding that developed within 2 weeks after the patient left the endoscopy unit

Secondary outcomes

  1. immediate postpolypectomy bleeding

    Time frame: during the polypectomy

    Blood spray or persistent oozing for more than 60 seconds requiring endoscopic intervention

  2. procedure time

    Time frame: during the polypectomy

    The duration from the appearance of the snare on the monitor to the time when the endoscope was withdrawn from the lesion

  3. en bloc resection

    Time frame: during the polypectomy

    Removal of a polyp with a single cut and was assessed by the colonoscopist

  4. complete histologic resection

    Time frame: during the polypectomy

    Clear resection margins, no polyp involvement

  5. use of haemostatic clips

    Time frame: during the polypectomy

  6. perforation rate

    Time frame: during the polypectomy, and interviewed by telephone on days 2 and 14 after polypectomy

    Proportion of patients with intraoperative or postoperative perforation

Study contacts

Contact information is provided by the study sponsor or research team.

Yanqing Li

CONTACT

[email protected]

+8653182169508

Sponsors and collaborators

Lead sponsor

Shandong University

Other

Registry information

Official study title

Efficacy and Safety of Cold Versus Hot Snare Polypectomy for Removal of 4-10 mm Pedunculated Colorectal Polyps: a Randomized Controlled Trial

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 20, 2025
Registry last updated
Apr 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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