Efficacy and Safety of Coenzyme Q10 in Pediatric Hemodialysis Patients

All chronic kidney disease patients, whether on regular hemodialysis or not, are at high risk of cardiovascular diseases. This is mainly due to increased oxidative stress, reduced antioxidants and generalized inflammation. Coenzyme Q10 is a vitamin-like antioxidant synthesized in almost all body cells, and it is also available in many dietary sources. It was observed that chronic kidney disease patients have low plasma levels of Coenzyme Q10. Clinical benefits of Coenzyme Q10 supplementation have been documented for various cardiovascular and neurodegenerative disorders. The investigators believe that Coenzyme Q10 supplementation may have potential benefits in pediatric patients receiving hemodialysis; mainly due to its antioxidant activity and anti-inflammatory effects.

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Key information

Conditions

Hemodialysis

Age range

2 year–18 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

El-Demerdash Children's Hospital

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male or female patients with ages between 2 to 18 years old.
Undergoing regular hemodialysis for at least 6 months.

Exclusion criteria

Patients who weigh less than 10 kg.

Treatment and study plan

Coenzyme Q10

Dietary Supplement

Oral capsules

Other names: ubiquinone, ubidecarenone, ubiquitous quinone

Placebo

Other

Oral capsules

Primary outcomes

Change in Malondialdehyde (MDA)

Time frame: 12 weeks

marker of oxidative stress

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Dec 28, 2021
Registry last updated: Jul 19, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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