Efficacy and Safety of CDP-choline in Patients With Methamphetamine Dependence

Inclusion criteria

• 19-60 year-old male or female
• Methamphetamine dependence diagnosed by DSM-IV
• Total cumulative dose for methamphetamine during the last two years: over 10 gram (over 200 shots of 0,05 mgram intravenous methamphetamine injection)
• Methamphetamine use in recent 4 weeks
• Subscale score of drug use in ASI: >2

Exclusion criteria

• Significant current or past medical, neurological, or psychiatric co-morbidity including cardiovascular, renal, and endocrine disorder, as identified by medical history
• Lifetime axis I psychiatric disorders of bipolar disorder, schizophrenia, identified by SCID-IV
• Socially dysfunctional antisocial personality disorder
• Current alcohol or nicotine dependence identified by SCID-IV
• Taking psychotropic medication in recent two months
• Head trauma history with loss of consciousness or seizure
• Intelligence quotient < 80
• Pregnant subjects. In addition, women of childbearing potential who will not practice a medically accepted method of contraception will be excluded. Female subjects who are of child-bearing potential will have to pass a urine pregnancy test before each visit.
• Any contraindication to an MR scan