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Completed

NCT Number: NCT04263259

Efficacy and Mechanisms of Mobile-Delivered Alcohol Attentional Bias Modification

This study evaluates the efficacy as well as psychological and neurobiological mechanisms of mobile-delivered alcohol attentional bias modification among heavy drinking adults.

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Key information

Conditions

Alcohol; Harmful Use

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Center on Alcoholism, Substance Abuse, & Addictions, Albuquerque, New Mexico, United States

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About this study

By testing the efficacy and neurobiological mechanisms of behavior change (MOBC) following attentional bias modification among heavy drinking adults, the proposed study has the potential to unify dual process models and neurobiological models of addiction. The cognitive retraining will be delivered via mobile electronic devices to ensure the cost-effectiveness of these procedures, to allow a large amount of retraining to be delivered in an ecologically valid manner, and to facilitate broad dissemination of such procedures if found to be efficacious. Using an intensive longitudinal experimental design, subjects will be randomly assigned into one of 2 groups (attentional bias modification vs. attentional bias control). Ecological momentary assessment (EMA) data will be used to assess changes in cognitive and behavioral measures in situ, and functional magnetic resonance imaging (fMRI) scans before and after cognitive retraining will be used to examine neural changes in specific regions of interest (ROI).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Alcohol Use Disorders Identification Test greater than or equal to 8
  • right-handed

Exclusion criteria

  • history of treatment for or diagnosis of alcohol use disorder/substance use disorder
  • history of brain injury
  • for females, currently pregnant
  • any MRI safety contraindication

Treatment and study plan

Attentional Bias Modification

Behavioral

Mobile-Delivered Cognitive Retraining Intervention

Other names: Cognitive Retraining

Primary outcomes

  1. Alcohol Use Frequency

    Time frame: 4 weeks

    Number of days of alcohol use during the 4-week ecological momentary assessment period

  2. Alcohol Use Quantity

    Time frame: 4 weeks

    Number of standard drinks per day during the 4-week ecological momentary assessment period

  3. Negative Alcohol-Related Consequences

    Time frame: 4 weeks

    Number negative consequences experienced 4-week ecological momentary assessment period

Secondary outcomes

  1. Attentional Bias to Alcohol

    Time frame: 4 weeks

    Measured with the Alcohol Dot Probe Task

  2. Alcohol Cue-Induced Neural Reward Circuit Activation

    Time frame: 4 weeks

    Regions of interest include ventral tegmental area, dorsal and ventral striatum

Sponsors and collaborators

Lead sponsor

University of New Mexico

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Feb 10, 2020
Registry last updated
May 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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