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NCT Number: NCT07012785

Efficacy Analysis of Saccharomyces Boulardii Combined With Minocycline in Treatment-naïve Patients With Helicobacter Pylori Infection

To assess the efficacy and safety of Saccharomyces boulardii combined with triple therapy containing minocycline in the initial eradication of Helicobacter pylori (H. pylori) infection

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Key information

Conditions

H. Pylori Infection

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18-70 years, regardless of gender;
  • Positive 13C/14C urea breath test result;
  • No previous history of H. pylori eradication treatment;
  • Agreement to participate in this study and signing of the informed consent form.

Exclusion criteria

  • History of ≥ 1 instance of failed H. pylori eradication;
  • Use of antibiotics (including antibacterial traditional Chinese medicines), nonsteroidal anti-inflammatory drugs (NSAIDS), bismuth agents, H2 receptor antagonists (H2RAs), proton-pump inhibitors (PPIs), and potassium-competitive acid blockers (P-CAB) within 4 weeks before treatment;
  • Plans to conceive, pregnancy, or breastfeeding;
  • Severe liver, kidney, or cardiovascular diseases; malignancies; and alcoholism;
  • Allergies to the drugs used in this study or a history of penicillin allergy;
  • The inability to correctly express one's symptoms and wishes, such as inability due to mental illness or severe neurosis.

Treatment and study plan

bismuth quadruple therapy

Drug

Bismuth quadruple therapy

Saccharomyces boulardii

Drug

Saccharomyces boulardii

Primary outcomes

  1. H. Pylori eradication rate

    Time frame: 7 days

Study contacts

Contact information is provided by the study sponsor or research team.

Lu Chen

CONTACT

[email protected]

13611569073

Sponsors and collaborators

Lead sponsor

Zhongda Hospital

Other

Registry information

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jun 10, 2025
Registry last updated
Jun 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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