Efficacy Analysis of Comparison of CAMS（Chinese Academy of Medical Sciences）-2005 Trial and CAMS-2009 Trial for Pediatric Acute Myeloid Leukemia

The investigators adopted the CAMS（Chinese Academy of Medical Sciences）-2009 trial for pediatric acute myeloid leukemia (AML) patients between 2009 to 2015, in which a risk-stratified strategy and dose-dense intensive chemotherapy were introduced. The outcomes of CAMS-2009 trial were retrospectively analyzed, and compared to the CAMS-2005 trial.

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Key information

Conditions

Acute Myeloid Leukemia, Pediatric Hematologic Diseases Hemic and Lymphatic Diseases Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Neoplasms Neoplasms by Histologic Type

Age range

6 month–16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

InstituteHBDH

Tianjin, Tianjin Municipality, 300020, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

newly diagnosed AML

Exclusion criteria

children with Down's syndrome and acute promyelocytic leukemia (APL)

Treatment and study plan

Risk-stratified therapy

Other

Dose-dense intensive chemotherapy and high dose of Ara-C in the consolidation therapy.

Primary outcomes

overall survival (OS)

Time frame: From date of diagnosed until the date of death from any cause, assessed up to 60 months

overall survival
event-free survival (EFS)

Time frame: From date of diagnosed until the date of first relapse or date of death from any cause, whichever came first, assessed up to 60 months

event-free survival
complete remission (CR)

Time frame: through study completion, an average of 1 year

fewer than 5% blast cells in the bone marrow aspirate and the absence of extramedullary involvement (EMI)

Sponsors and collaborators

Lead sponsor

Institute of Hematology & Blood Diseases Hospital, China

Other

Registry information

Official study title

Efficacy Analysis of Comparison of CAMS-2005 Trial and CAMS-2009 Trial for Pediatric Acute Myeloid Leukemia

Important dates

Study start: 2005
Primary completion: 2012
Study completion: 2015
First posted: May 24, 2017
Registry last updated: Feb 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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