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Completed

NCT Number: NCT03469037

Effects on Experimental Dyspnea of High Flow Nasal Cannula

To develop an experimental model of dyspnea by external thoraco-abdominal elastic strapping at rest in order to study the mechanisms involved in the relief of dyspnea by the administration of high flow by nasal cannula (HFNC).

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Key information

Conditions

Dyspnea Healthy Volunteers Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Laboratoire de Physiopathologie Respiratoire du Service de Pneumologie et de Réanimation, Paris, France

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About this study

This study will measure the effect of HFNC on an experimental model of dyspnea induced by thoraco-abdominal elastic strapping on healthy subjects at rest.

The study will also compare the effects on dyspnea of the administration of high flow nasal cannula with and without oxygen added.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers

Exclusion criteria

  • chronic pathology
  • active smokers
  • anxiety disorder
  • allergy to latex
  • protected adult
  • woman declared herself pregnant

Treatment and study plan

Optiflow with an inspired fraction of oxygen of 100%

Device

Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 100%

Other names: High flow nasal cannula with oxygen added

Optiflow with an inspired fraction of oxygen of 21%

Device

Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 21%

Other names: High flow nasal cannula without oxygen added

Primary outcomes

  1. Effects of high flow nasal cannula on strapping induced type of dyspnea

    Time frame: One hour

    Evaluated by visual annylogic scale

Secondary outcomes

  1. Compare the effect of the high flow by nasal cannula with and without oxygen on an experimental dyspnea, evaluated by the differences of changes in the visual analogic scale

    Time frame: One hour

    Evaluated by visual annylogic scale

Sponsors and collaborators

Lead sponsor

Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Other

Registry information

Official study title

Effects on an Experimental Dyspnea by Thoraco-abdominal Elastic Strapping of the High Flow Nasal Cannula

Acronym: EDEN

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Mar 19, 2018
Registry last updated
Feb 15, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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