Effects of Zinc Supplementation on Anthropometric Factors, Apelin and Inflammatory Markers in Obese Individuals

To study the effects of zinc supplement on anthropometric factors, Apelin and inflammatory markers in obese individuals, 50 obes person who referred to Diet and Nutrition clinic of Shahid Beheshti University of Medical Sciences will be randomly allocated to receive 50 mg zinc capsules or placebos for 15 weeks; both groups will be advised to adherence the investigators' diet . At the first and the end of the intervention,weight, body mass index (BMI), waist circumference, fat mass and lean body mass, concentration of zinc, albumin, hs-CRP, TNF-α and plasma apelin will be assessed and compared between groups.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age of 18 to 45 years
Non-smoking
Body Mass Index (BMI) more than 30

Exclusion criteria

Pregnancy, lactation or menopause in women
History of liver disease, kidney, thyroid, diabetes and other metabolic diseases
Use of drugs interfering with lipid profile, blood-thinning drugs, beta-blockers
Patients with immune deficiency
Use of zinc, calcium and iron supplement in the last 2 months
Use of weight loss medication or special diet
Following program to lose weight in recent 2 months
Recent surgery

Treatment and study plan

zinc sulfate

Dietary Supplement

1 zinc sulfate capsule for 15 weeks

corn starch

Other

1 corn starch capsule for 15 weeks

Other names: placebo

Primary outcomes

weight

Time frame: 15 weeks

Sponsors and collaborators

Lead sponsor

National Nutrition and Food Technology Institute

Other

Registry information

Official study title

Effects of Zinc Supplementation on Weight, Body Mass Index (BMI), Waist Circumference, Fat Mass and Lean Mass, Apelin and Inflammatory Markers in Obese Individuals

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: Aug 6, 2015
Registry last updated: Aug 6, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed