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Completed

NCT Number: NCT05353270

Effects of Yoga on Sodium-induced Pressor Responses in African American Adults

This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.

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Key information

Conditions

Blood Pressure

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cardiovascular Physiology Laboratory-Texas State University

San Marcos, Texas, 78666, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • African American
  • Adults ages 18-60 years

Exclusion criteria

  • pregnancy or within 60 days postpartum
  • having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months (statins have been demonstrated to reduce oxidative stress which could impact flow-mediated dilation);
  • infection (viral or other) within the past 4 weeks;
  • having adrenal or endocrine tumors (these could impact BP);
  • renal disease defined as a glomerular filtration rate (GFR) of less than 60 (creatinine will be tested at initial screening and GFR will be calculated);
  • prior myocardial infarction; vii) known coronary heart disease;
  • personal history of stroke;
  • heart failure;
  • cardiac arrhythmias;
  • chronic obstructive pulmonary disease;
  • recent chest pain or dyspnea;
  • orthopedic limitations that preclude the execution of yoga postures;
  • current insulin dependence;
  • currently taking steroid medications;
  • currently undergoing chemotherapy or radiation;
  • having practiced yoga or yogic breathing techniques at least once weekly consistently within the past 3 months;
  • heat intolerance or electrolyte imbalances (hypo- or hyper-natremia or hypo- or hyper-kalemia).

Treatment and study plan

Yoga

Behavioral

Yoga sessions will be completed 5 times per week for 4 weeks.

Waitlist Control

Behavioral

Waitlisted participants will maintain their normal exercise and diet for 4 weeks. After follow up testing at week 4, participants will be rerandomized to the yoga condition.

Primary outcomes

  1. Change in blood pressure from low- to high-sodium dietary conditions

    Time frame: Measurements will be completed after 3 days of low and 3 days of high sodium intake at baseline and after 4 weeks for both conditions.

    Blood pressure will be measured after 3 days of very low sodium and 3 days of high sodium intake.

  2. Change in endothelial function from low- to high-sodium dietary conditions.

    Time frame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

    Flow-mediated dilation will be measured via ultrasound imaging of the upper arm after 3 days of low- and 3 days of high- sodium dietary conditions.

  3. Change in arterial stiffness from low- to high-sodium dietary conditions.

    Time frame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

    Cardio-ankle vascular index will be measured after 3 days of low- and 3 days of high-sodium intake.

Secondary outcomes

  1. Change in urinary sodium excretion from low- to high-sodium dietary conditions.

    Time frame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

    24-hour urine collection will be completed after 3 days of low- and after 3 days of high-sodium dietary conditions.

Sponsors and collaborators

Lead sponsor

Texas State University

Other

Registry information

Official study title

Effects of Yoga on Pressor and Endothelial Function in Responses to Sodium Loading in African American Adults

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Apr 29, 2022
Registry last updated
Apr 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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