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OpenTrials
Completed

NCT Number: NCT03164590

Effects of Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Cytokines

This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on inflammatory cytokine response after total abdominal hysterectomy.

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Key information

Conditions

Endometrial Adenocarcinoma

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

South Egypt Cancer instIitute

Asyut, 171516, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-II patients
  • age range (18-60) years,
  • weight (50- 90) kg

Exclusion criteria

  • allergy to study drugs
  • significant cardiac disease
  • respiratory disease
  • renal disease
  • hepatic disease

Treatment and study plan

ketamine

Drug

patients receive local anesthetic wound infiltration with 1 mg /kg ketamine

Dexmedetomidine

Drug

patients receive local anesthetic wound infiltration with 1µg/kg dexmedetomidine

Bupivacaine

Drug

patients receive local anesthetic wound infiltration with bupivacaine 0.5 % diluted in 20 ml saline

Primary outcomes

  1. severity of pain at rest and on coughing

    Time frame: 24 hours

    severity of pain at rest and on coughing will be assessed using a 10-cm Visual Analog Scale (0 = no pain and 10 = worst imaginable pain)

Secondary outcomes

  1. sedation

    Time frame: 24 hours

    sedation by using sedation score

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Inflammatory Cytokines Response After Total Abdominal Hysterectomy

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
May 23, 2017
Registry last updated
Jan 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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