Effects of Whole-Body Vibration Exercise on Serum IGF-1 in Fibromyalgia

The purpose of this study was to investigate the acute and chronic effect of whole-body vibration exercise on serum insulin-like growth factor-1 levels in women with fibromyalgia (FM). It was hypothesized that women with FM would exhibit an increase in IGF-1 following both acute and chronic WBV. Twenty-four women with FM were randomized into two groups: Vibration Group (VG) and Control Group (CG). The VG underwent a protocol with WBV exercise twice a week for a total of six weeks, whereas the CG performed the same protocol without vibratory stimulus. Both groups continued with their usual pharmacological treatment. Serum IGF-1 levels were determined using Enzyme-Linked Immunosorbent Assay (ELISA). To test the effect of chronic WBV, serum IGF-1 measurements were taken at baseline and at weeks 1,3, and 6 of intervention. To test the effect of acute WBV, within week 1, serum IGF-1 measurements were taken before and immediately following a session of WBV.

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Key information

Conditions

Fibromyalgia Behavior Hormonal Responses to Exercise in Patients With Fibromyalgia. Motor Activity Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neuromuscular Diseases Rheumatic Diseases

Age range

35 year–69 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Institut Nacional d'Educación Física de Catalunya

Barcelona, 08038, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients diagnosed of fibromyalgia according to the American College of Rheumatology criteria for at least three years.

Exclusion criteria

Orthopedic limitation, or cardiovascular, pulmonary, or metabolic disease that would preclude exercise.
Participation in any other study.

Treatment and study plan

Vibratory platform, PowerPlate®, Badhoevendorp, Netherlands

Device

Six exercises (static and dynamic tasks) while standing on a Whole-body vibration platform. The six exercises (30 seconds each) were repeated six times with a recovery of 3 minutes in between. The Whole-body vibration intensity was kept constant at 30 Hz of frequency and 2 mm of amplitude.

Placebo Whole-body vibration exercise

Device

Six exercises (static and dynamic tasks) while standing on a Whole-body vibration platform. The six exercises (30 seconds each) were repeated six times with a recovery of 3 minutes in between. All exercises were performed without the influence of a vibratory stimulus.

Primary outcomes

Serum IGF-1 levels

Time frame: Baseline, Week 1, Week 3, Week 6

Sponsors and collaborators

Lead sponsor

Institut Nacional d'Educacio Fisica de Catalunya

Other

Registry information

Official study title

Effect of Acute and Chronic Whole-Body Vibration Exercise on Serum Insulin-Like Growth Factor-1 Levels in Women With Fibromyalgia

Important dates

Study start: 2004
Primary completion: 2005
Study completion: 2005
First posted: Apr 2, 2008
Registry last updated: Apr 2, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed