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OpenTrials
Completed

NCT Number: NCT00936039

Effects of Unloading on Muscle Mass

In the present study, the effects of 3 weeks of unloading on muscle mass and muscle fiber characteristics will be determined. In addition, the effects of 6 weeks of recovery will be assessed.

Completed

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Key information

Conditions

Immobilization Behavior Physical Inactivity Sedentary Behavior

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre

Maastricht, 6200MD, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • BMI < 30 kg/m2

Exclusion criteria

  • Use of medication that may affect haemostasis
  • Subjects with (recent) musculoskeletal/orthopaedic disorders known to affect the outcome of the study or that compromise their ability to walk with crutches
  • Subjects with metal implants in their lower limbs
  • Subjects with known cardiovascular and/or haemostasis disorders
  • Subjects with known severe hypertension

Treatment and study plan

unloading

Behavioral

2 weeks of unloading of a single leg

Primary outcomes

  1. muscle mass, muscle fiber size

    Time frame: 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading

Secondary outcomes

  1. muscle strength

    Time frame: 1 week before unloading; immediately (1 day) after unloading and 6 weeks after unloading

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Official study title

The Effect of Immobilization on Myocellular Characteristics in Healthy, Young Males

Important dates

Study start
2009
Primary completion
2013
Study completion
2013
First posted
Jul 9, 2009
Registry last updated
Jul 2, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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