EFFECTS OF TWO ANESTHESİA TECHNİQUES ON INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY

The main aim of this study is to compare the effects of two different anesthesia methods-(1) general anesthesia alone and (2) combination of general anesthesia with cervical plexus block-on postoperative inflammatory process and amino acid metabolism in patients undergoing thyroidectomy.

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Key information

Conditions

General Anesthesia Cervical Plexus Block Thyroid Surgery

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

This includes patients aged 18-70 years
classified as ASA I-III
who have undergone elective thyroidectomy.

Exclusion criteria

Patients who did not wish to participate in the study voluntarily
patients for whom superficial cervical block was contraindicated
pregnant and breastfeeding women
patients in ASA IV-V groups were excluded from the study.

Treatment and study plan

General Anesthesia

Procedure

In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block.

The inflammatory response is a natural response of the body's immune system to surgical trauma, and it can vary depending on the anesthetic agent used. In regulating this response, molecules such as IL-1β, TNF-α, IL-6, IL-10, and IL-40 are important indicators that determine the severity and duration of inflammation. These parameters will be examined and compared in both groups.

cervical plexus block

Procedure

In our study, one patient group will receive only general anesthesia, while the other group will receive general anesthesia in addition to ultrasound-guided cervical plexus block.

Primary outcomes

Perioperative Inflammatory Response

Time frame: Before the procedure, and at 2 and 6 hours after the procedure.

IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.
Inflammatory Response

Time frame: Before the procedure, and at 2 and 6 hours after the procedure.

IL-1β, TNF-α, IL-6, IL-10, and IL-40 levels will be measured 1 hour before surgery, and then 2 and 6 hours after surgery, and these values will then be compared.

Study contacts

Contact information is provided by the study sponsor or research team.

Abdulhakim Şengel

CONTACT

[email protected]

+905374030916

Sponsors and collaborators

Lead sponsor

Harran University

Other

Registry information

Official study title

THE EFFECT OF TWO DİFFERENT ANESTHESİA APPROACHES ON PERİOPERATİVE INFLAMMATORY RESPONSE AND AMİNO ACİD METABOLİSM İN THYROİD SURGERY

Important dates

Study start: 2026
Primary completion: 2027
Study completion: 2027
First posted: May 18, 2026
Registry last updated: May 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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