Effects of Transcutaneous Electrical Nerve Stimulation on Cortical Excitability in the Primary Motor Cortex in Healthy Adults

Recently, non-invasive brain stimulation has become a powerful tool in both basic research and clinical application. Among several non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have received the most attention. About DC stimulation, the change of polarity could modulate the spontaneous neuronal activity and make effect on decision making, language, memory, sensory perception, and pain. In spite of that the concept of transcranial alternating current stimulation (tACS) is not novel, AC is relatively safe compared to DC, and researches have revealed that AC might potentially have the effect on the cortical excitability. However, there are still many areas about AC stimulation which remain unknown, such as mechanism, application, and potential influence on cortical excitability.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Transcutaneous Electrical Nerve Stimulation

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chang Gung University

Taoyuan, 333, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy adults

Treatment and study plan

transcutaneous electrical nerve stimulation, TENS

Device

Then participants will receive stimulation for 20 minutes.

Primary outcomes

Motor evoked potential

Time frame: Baseline

measure of intracortical inhibition on abductor pollicis brevis by single-pulse TMS.
Intracortical inhibition, ICI

Time frame: Baseline,2 hours, 2.5 hours,and 3 hours

Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.
intracortical facilitation, ICF

Time frame: Baseline,Baseline,2 hours, 2.5 hours,and 3 hours

Measure of changes in intracortical inhibition on abductor pollicis brevis by paired-pulse TMS.

Sponsors and collaborators

Lead sponsor

Chang Gung University

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2013
First posted: Mar 4, 2014
Registry last updated: Mar 4, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed