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OpenTrials
Completed

NCT Number: NCT00740701

Effects of Transcranial Magnetic Stimulation to the Cerebellum on Cognition

Functional neuroimaging studies have shown that the cerebellum is active during cognitive performance. The investigators hypothesize that stimulation of the cerebellum with transcranial magnetic stimulation will produce brief changes in performance of the task, suggesting that cerebellar activation is necessary for normal cognitive function.

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Key information

Conditions

Cognitive Performance

Age range

19 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 19-30 years of age
  • Informed consent

Exclusion criteria

  • History of seizure or a family history of epilepsy
  • History of stroke
  • Presence of metal anywhere in the head except the mouth
  • Presence of cardiac pacemakers
  • Presence of cochlear implants
  • Presence of implanted medication pump
  • History of heart disease
  • Presence of intracardiac lines
  • Increased intracranial pressure, such as after infarctions or trauma
  • Children, or outside of age range
  • Pregnancy
  • Currently taking tricyclic anti-depressants or neuroleptic medication
  • History of head trauma
  • History of respiratory disease

Treatment and study plan

Cerebellar transcranial magnetic stimulation

Device

single pulse TMS or repetitive TMS at 1 Hz frequency

Primary outcomes

  1. Behavioral performance (accuracy, or rate of conditioned responses)

    Time frame: during computerized task performance (2 hours)

Secondary outcomes

  1. Reaction time

    Time frame: during performance of computerized task (2 hours)

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Collaborators

  • National Institute of Mental Health (NIMH)
  • National Institute on Aging (NIA)

Registry information

Official study title

fMRI and TMS Analysis of Cerebellar Cognitive Function

Important dates

Study start
2000
Primary completion
2005
Study completion
2005
First posted
Aug 25, 2008
Registry last updated
Aug 24, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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