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Completed

NCT Number: NCT06343142

Effects of Time of Day and Nut Intake on Cognitive Performance

This is a 2 x 2-factor crossover design study to investigate the effects of time of day and nuts on post-meal cognitive performance.

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Key information

Conditions

Cognitive Performance

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutrition, Dietetics and Food - Monash University

Notting Hill, Victoria, 3168, Australia

About this study

In this trial, eligible participants will receive isocaloric meals with or without nuts at lunchtime and dinner time. Cognitive performance will be performed before and 90 min after the meals.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Non-shift workers
  • 18-55 years
  • BMI between 18.5 and 27 kg/m2,
  • Non-smokers
  • Without chronic illnesses

Exclusion criteria

  • Allergy to nuts
  • BMI<18.5 or >27 kg/m2
  • Presence of dementia or psychiatric disease (depression, Parkinson's disease, schizophrenia)
  • Presence of diabetes, serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery, cardiovascular disease
  • Presence of any sleep disorders
  • Taking anti-diabetic or lipid-lowering medication
  • Do not speak English
  • Pregnant or planning on becoming pregnant
  • Breastfeeding

Treatment and study plan

Nuts

Other

Isocaloric meal with nuts

Nut-free meal

Other

Isocaloric meal without nuts

Primary outcomes

  1. N-back task - accuracy

    Time frame: before meal x 90 min post-meal

    Difference in the total accuracy

  2. N-back task - matched responses

    Time frame: before meal x 90 min post-meal

    Difference in the % matched responses

  3. N-back task - false alarm

    Time frame: before meal x 90 min post-meal

    Difference in the % false alarm

  4. N-back task - reaction time

    Time frame: before meal x 90 min post-meal

    Difference in the reaction time for correct matched responses

  5. Stroop test - congruent

    Time frame: before meal x 90 min post-meal

    Difference in the reaction time for congruent

  6. Stroop test - incongruent

    Time frame: before meal x 90 min post-meal

    Difference in the reaction time for incongruent

  7. Stroop test - interference

    Time frame: before meal x 90 min post-meal

    Difference in stroop interference (incongruent - congruent response time)

Secondary outcomes

  1. Multitasking - pure blocks

    Time frame: before meal x 90 min post-meal

    Difference in the reaction time for pure blocks

  2. Multitasking - mixed blocks

    Time frame: before meal x 90 min post-meal

    Difference in the reaction time for mixed blocks

  3. Multitasking - mixing cost

    Time frame: before meal x 90 min post-meal

    Difference in mixing cost (mixed - pure reaction time)

  4. Satiety - hunger

    Time frame: Hunger will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).

    Difference in postprandial hunger

  5. Satiety - fullness

    Time frame: Fullness will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).

    Difference in postprandial fullness

  6. Satiety - satisfaction

    Time frame: Satisfaction will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).

    Difference in postprandial satisfaction

  7. Satiety - eating capacity

    Time frame: Eating capacity will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).

    Difference in postprandial eating capacity,

  8. Satiety index

    Time frame: Satiety index will be assessed before the meal and 4 times after the meal (15, 30, 60 and 90 mins).

    Difference in postprandial satiety index, calculated using the mean of the four satiety questions, where "hunger" and "eating capacity" will be scored in an inverse way than "fullness" and "satisfaction".

Sponsors and collaborators

Lead sponsor

Monash University

Other

Registry information

Official study title

Effects of Time of Day and Nut Intake on Cognitive Performance: a Crossover Trial in Healthy Adults

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Apr 2, 2024
Registry last updated
Nov 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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