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Completed

NCT Number: NCT02890680

Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery

The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.

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Key information

Conditions

Fibrin/Therapeutic Use Blood Platelets Bone Regeneration Molar, Third

Age range

16 year–29 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

João Canellas

Rio de Janeiro, 24240170, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy patients
  • Preoperative platelet count higher than 150,00/ mm3
  • Patient who required bilateral mandibular third molar extractions

Exclusion criteria

  • Smokers patients
  • Alcoholics patients
  • Patients whom the inferior second molar was missing
  • Patients who had acute pericoronitis on the inferior third molar
  • Severe periodontal disease

Treatment and study plan

Platelet-rich fibrin

Procedure

Control Group

Procedure

Primary outcomes

  1. Change in bone density through tomography evaluation

    Time frame: Change from Baseline bone measurement at three months after surgery

Secondary outcomes

  1. Change in periodontal-probing depth measurement on distal aspect of the second molar through Clinical evaluation

    Time frame: Change from baseline at 3 months after surgery

  2. Pain through Visual Analogue Scale

    Time frame: 1st day after surgery

  3. Pain through Visual Analogue Scale

    Time frame: 3rd day after surgery

  4. Pain through Visual Analogue Scale

    Time frame: 7th day after surgery

  5. Soft tissue healing through Clinical evaluation numeric scale

    Time frame: 7th day after surgery

Sponsors and collaborators

Lead sponsor

Rio de Janeiro State University

Other

Registry information

Official study title

Randomized Double Blind Clinical Trial Evaluation of Bone Regeneration After Impacted Third Molar Surgery With the of Platelet-rich Fibrin: Pilot Study

Important dates

Study start
2016
Primary completion
2016
Study completion
2017
First posted
Sep 7, 2016
Registry last updated
Apr 12, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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