Skip to main content
OpenTrials
Completed

NCT Number: NCT04276324

Effects of Ten-Weeks Power Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universidad Católica San Antonio

Murcia, 30107, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • mild or moderate disability with clinical mild spastic-ataxic gait disorder.
  • stable phase of the disease.

Exclusion criteria

  • Expanded Disability Status Scale (EDSS) < 6.
  • relapsing disease within the preceding 12 months.
  • corticosteroid treatment within the last months before study inclusion.

Treatment and study plan

Resistance training

Other

Ten weeks of resistance training

Testing sessions

Other

Testing sessions

Primary outcomes

  1. Maximal Voluntary Isometric Contraction of Knee Extension

    Time frame: Before the program training

  2. Maximal Voluntary Isometric Contraction of Knee Extension

    Time frame: After 10 weeks

  3. Rate of Force Development

    Time frame: Before the program training

  4. Rate of Force Development

    Time frame: After 10 weeks

  5. Central Activation Ratio

    Time frame: Before the program training

  6. Central Activation Ratio

    Time frame: After 10 weeks

  7. Spasticity

    Time frame: Before the program training

    Pendulum test

  8. Spasticity

    Time frame: After 10 weeks

    Pendulum test

Secondary outcomes

  1. Walking speed

    Time frame: Before the program training

    Test 10 m-walks

  2. Walking speed

    Time frame: After 10 weeks

    Test 10 m-walks

  3. Static balance

    Time frame: Before the program training

    Romberg Test with eyes open and closed. Analysis with force plates

  4. Static balance

    Time frame: After 10 weeks

    Romberg Test with eyes open and closed. Analysis with force plates

  5. Functional capacity

    Time frame: Before the program training

    Sit to stand test

  6. Functional capacity

    Time frame: After 10 weeks

    Sit to stand test

  7. Heart Rate Variability

    Time frame: Before the program training

    Sleeping Heart Rate Variability

  8. Heart Rate Variability

    Time frame: After 10 weeks

    Sleeping Heart Rate Variability

  9. Sleep Quality

    Time frame: Before the program training

    Karolinska Sleep Diary and Acelerometry

  10. Sleep Quality

    Time frame: After 10 weeks

    Karolinska Sleep Diary and Acelerometry

Sponsors and collaborators

Lead sponsor

Universidad Católica San Antonio de Murcia

Other

Registry information

Official study title

Effects of Ten-Weeks Resistance Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Feb 19, 2020
Registry last updated
Oct 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.