Effects of tDCS Versus HD-tDCS for Stroke Rehabilitation

The purpose of this study is to assess the changes in language processing of patients with chronic aphasia after receiving non-invasive brain stimulation.Previous research using traditional transcranial direct current stimulation (tDCS) using 2 sponge electrodes has shown that persons with aphasia show more improvement after treatment when that treatment is accompanied by brain stimulation. Traditional tDCS has recently been modified to deliver current to more specific locations in the brain. This new delivery method is called high-definition tDCS (HD-tDCS). It is not known whether traditional tDCS (more diffuse current delivery) or HD-tDCS (more focal current delivery) will be the better approach for enhancing treatment outcomes. To answer this question, computerized speech-language treatment will be administered during the application of the different forms of brain stimulation.

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Key information

Conditions

Chronic Aphasia Anomia Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Communication Disorders Language Disorders Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Stroke Vascular Diseases

Age range

25 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

one-time ischemic stroke in the left hemisphere
greater than 6-months post-stroke onset
between 25 and 80 years of age
aphasia diagnosis (as determined by pre-treatment language-based testing)
right-handed (before the stroke)
native speaker of English
ability to provide informed written or verbal consent

Exclusion criteria

clinically reported history of dementia, alcohol abuse, psychiatric disorder, traumatic brain injury, or extensive visual acuity or visual-spatial problems
factors contraindicative of tDCS administration (sensitive scalp, previous brain surgery)
prior history of epileptic or unprovoked seizures occurring during the previous 12 months.

Treatment and study plan

HD-tDCS (Soterix)

Device

Subjects will be given individualized dose (number of electrodes and electrode placement) through High-Definition electrodes to target fMRI determined targets

Other names: Soterix Medical High-Definition M x N stimulator, Soterix Medical HDTargets

Transcranial Direct Current Stimulation (Neuroconn)

Device

Other names: Neuroconn

Sponsors and collaborators

Lead sponsor

Soterix Medical

Industry

Collaborators

National Institute of Neurological Disorders and Stroke (NINDS)

Registry information

Official study title

High Definition-transcranial Direct Current Stimulation (HD-tDCS) for Stroke Rehabilitation

Acronym: tDCS- Aphasia

Important dates

Study start: 2012
Primary completion: 2012
Study completion: 2013
First posted: Jul 27, 2012
Registry last updated: Aug 26, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed