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OpenTrials
Completed

NCT Number: NCT02109796

Effects of tDCS on Quadriceps Strength After Stroke

Previous studies show that one session of tDCS allow to improve muscle strength in hemiparetic patients in anodal condition. We test a new electrods configuration : a anodale stimulation opposite to the cortical representation area of the injured hemisphere and a simultaneous stimulation opposite to the homonyme the cortical representation area of the healthy hemisphere. This approach seems to be the best relevant electrods configuration in order to restore the inter-hemispheric balance.

We hypothesis that one session of tDCS with this electrods configuration allow to improve paretic quadriceps strength in hemiparetic patients after stroke.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Muscle Hypertonia Muscle Spasticity Muscular Diseases Musculoskeletal Diseases Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Raymond Poincare Hospital

Garches, 92380, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • written consent
  • hemiparetic patient after stroke in chronic phase (> 6 months)
  • capacity to walk with or without technical assistance
  • following rehabilitation program for lower limbs

Exclusion criteria

  • patient with bilateral brain lesion, cerebellar syndrom, and apraxia and/or aphasia
  • previous orthopedic surgery in paretic lower limb (<6 moths)
  • usual tDCS contraindications
  • pregnant woman

Treatment and study plan

Transcranial Direct Current Stimulation

Device

Primary outcomes

  1. maximum voluntary isometric strength of knee extensors

    Time frame: 2 hours

    The maximum voluntary isometric strength of paretic knee extensors will be evaluated with a isokinetic dynamometer, which measure peak torque.

Secondary outcomes

  1. Resistive peak torque during passive knee flexion

    Time frame: 2h

  2. Angle related to the resistive peak torque generation of the knee extensors

    Time frame: 2h

  3. Amplitude of the interpolation twitch

    Time frame: 2h

  4. EMG activation of the knee flexors and extensors during the strength evaluations (active and passive)

    Time frame: 2h

  5. Functional evaluation of the gait performance and balance

    Time frame: 2h

Sponsors and collaborators

Lead sponsor

Centre d'Investigation Clinique et Technologique 805

Other

Collaborators

  • Fondation Garches

Registry information

Official study title

a Controlled, Randomized Study Evaluating the Immediate Effect of One tDCS Session on Quadriceps Strength in Hemiparetic Patients.

Acronym: tDCS(HE)

Important dates

Study start
2015
Primary completion
2016
Study completion
2017
First posted
Apr 10, 2014
Registry last updated
Nov 14, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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