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Completed

NCT Number: NCT04432363

Effects of tDCS in M1 and DLPFC on Pain Processing in Healthy Volunteers

The purpose of this study is to evaluate the effects of a direct current applied transcranial over two cortical areas on healthy volunteers' pain processing.

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Key information

Conditions

Pain Processing in Healthy Volunteers

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Universidad Rey Juan Carlos

Alcorcón, Madrid, 28922, Spain

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 40 years
  • Comprehension of the study tasks

Exclusion criteria

  • Presence of pain in the previous 6 months
  • Altered sensitivity in the tested regions
  • Intolerance to electrotherapy
  • Presence of pacemakers or any other implanted device
  • Ulcers or scars in the skin at the location of the electrodes
  • Treatment with direct current stimulation within one week
  • Pregnancy
  • Frequent headaches
  • Epilepsy
  • History of neuromuscular disease
  • Previous clinical history of cervical surgery
  • Injuries or surgery affecting the upper limb
  • diabetes mellitus
  • Cardiovascular diseases
  • Oncological diseases
  • Consumption of analgesic drugs 7 days before the study

Treatment and study plan

Transcranial Direct Current Stimulation

Device

Direct current application over the scalp to stimulate and change the excitability of the cortical areas underneath the electrodes (in this case left primary motor cortex and left dorsolateral prefrontal cortex).

Primary outcomes

  1. Conditioned Pain Modulation

    Time frame: Pre-intervention and immediately after treatment

    Pain pressure threshold change after a painful ischemic stimulus

  2. Pain pressure algometer temporal summation

    Time frame: Pre-intervention and immediately after treatment

    Change in pain perceived between the first and tenth painful pressure stimulus

Secondary outcomes

  1. Pain pressure threshold

    Time frame: Pre-intervention and immediately after treatment

    Measurement of pressure applied until the perception of pain

  2. Pain pressure tolerance

    Time frame: Pre-intervention and immediately after treatment

    Measurement of maximal painful pressure tolerate using a pressure algometer

  3. Neural mechanosensitivity

    Time frame: Pre-intervention and immediately after treatment

    Measurement of range of motion achieved until the perception of tension

  4. Cold hyperalgesia with a cold pack

    Time frame: Pre-intervention and immediately after treatment

    Pain rated in a visual analogue scale after 10 seconds of a cold stimulus

  5. Isometric grip strength

    Time frame: Pre-intervention and immediately after treatment

    Maximal pressure achieved in a isometric gripping task

Sponsors and collaborators

Lead sponsor

Universidad Rey Juan Carlos

Other

Registry information

Official study title

Effects of Transcranial Direct Current Stimulation on Primary Cortex and Prefrontal Dorsolateral Cortex in Pain Processing on Healthy Volunteers: A Triple Blind Randomized Controlled Trial.

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jun 16, 2020
Registry last updated
Oct 30, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.