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OpenTrials
Completed

NCT Number: NCT03497468

Effects of Task-oriented Training on Functional Mobility and Fatigue in Patients With Multiple Sclerosis

Multiple Sclerosis (MS) is inflammatory, demyelinating and autoimmune disease of the central nervous system. It is usually seen with relapses and genetic and environmental factors play a role in the etiology. Neurological symptoms seen in MS restrict the patient's daily activity and social role participation. Mobility problems and fatigue are the most important reasons of role limitations and decreased quality of life. The importance of exercise training in disease management has been emphasized in recent years. However, few studies have investigated the effects of task-oriented trainings on symptoms of the disease. The aim of this sudy is to investigate the effects of task-oriented training additional to combined exercise training on functional capacity, mobility, balance, fatigue and quality of life in patients with MS.

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Key information

Conditions

Multiple Sclerosis, Relapsing-Remitting Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Fatigue Immune System Diseases Multiple Sclerosis Nervous System Diseases Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Multiple Sclerosis diagnosis
  • Expanded Disability Status Scale > 5,5
  • No cognitive problems
  • No relapses in the last 3 months
  • No other neurological or chronic disease

Exclusion criteria

  • Relapse during the intervention
  • Exercise intolerance

Treatment and study plan

Combined Exercise Training

Other

Aerobic training with cycle ergometer %60-80 of maximal Heart Rate, submaximal level, strengthening of the major muscles of upper and lower extremities

Task-Oriented Training

Other

Functional reaching, walking on different obstacles and floor,sitting and standing on different levels and surface,walking around obstacle, climbing stairs with different height and surface

Primary outcomes

  1. Functional capacity

    Time frame: 6 weeks

    Change from baseline functional capacity with six minute walking test

Secondary outcomes

  1. dynamic gait skills

    Time frame: 6 weeks

    Change from baseline functional mobility with dynamic gait index

  2. limitation of gait

    Time frame: 6 weeks

    Change from baseline functional mobility with MS walking scale-12

  3. dynamic balance and fall risk

    Time frame: 6 weeks

    Change from baseline functional mobility with timed up and go test

  4. sitatic balance

    Time frame: 6 weeks

    Change from baseline balance with functional reach test

  5. dynamic balance

    Time frame: 6 weeks

    Change from baseline balance with berg balance scale

  6. severity of fatigue

    Time frame: 6 weeks

    Change from baseline fatigue with fatigue severity scale

  7. impact of fatigue

    Time frame: 6 weeks

    Change from baseline fatigue with fatigue impact scale

  8. Quality of life

    Time frame: 6 weeks

    Change from baseline quality of life with MS quality of life instrument-54

Sponsors and collaborators

Lead sponsor

Bezmialem Vakif University

Other

Registry information

Important dates

Study start
2017
Primary completion
2017
Study completion
2018
First posted
Apr 13, 2018
Registry last updated
Jul 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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