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NCT Number: NCT05129917

Effects of Supplementation With Ginseng and BCAA Improved Central Fatigue and Enhanced Attention During Exercise

The main purpose of the present study is to determine the effects of acute and short-term (14 days) ginseng combined with branch chained amino acids supplementation on endurance exercise performance and the ability of anti-fatigue. In addition, this study also measured the performance of continuous attention during recovery period to examine the effect of supplementation on central fatigue.

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Key information

Conditions

Exercise Addiction

Age range

20 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Muscle fatigue was a common problem after exercise. When fatigue occured, body functions were affected and changed. Changbai Mountain ginseng had higher anti-fatigue substances than general commercial ginseng. And recent studies had showed that the supplementation of branched chain amino acids (BCAA), including leucine, isoleucine and valine, can increase attention and reduce fatigue. However, its effect on Changbai Mountain ginseng combined with BCAA was still unclear. Subjects were allocated to Gojinsen® drinks and placebo group (1:1 ratio) for 14 days, and then examined by maximal oxygen consumption, time to exhaustion, rating of perceived exertion (RPE), oxygen saturation (SPO2) , blood lactate concentration, and continuous attention performance test (CPT II). The Gojinsen® group significant increased maximal oxygen consumption, time to exhaustion, and attention compared to placebo group. Moreover, the Gojinsen® group significant decreased lactate concentration and fatigue compared to placebo group. By this study, Gojinsen® drinks did not showed absolute anti-fatigue effect but provided the objective evidence of fatigue-related measurement and the therapeutic potential for people suffering from exercise fatigue.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy male and female adults aged 20-25 years old .
  • without heart, liver, kidney, endocrine or other major organic diseases).
  • had at least 3 months experience in performing exercise

Exclusion criteria

  • BMI of the study subjects must be less than 25.

Treatment and study plan

Placebo

Dietary Supplement

consume 1 sachet per day for 14 day

Gojinsen® drinks

Dietary Supplement

consume 1 sachet per day for 14 day

Primary outcomes

  1. Endurance exercise performance testing

    Time frame: Execution on the 14th day

    the subjects arrived to the laboratory and wore the oxygen uptake mask of energy metabolism analyzer (Sensor Medics, Vmax29, USA) to measure the subjects' oxygen uptake

  2. rating of perceived exertion

    Time frame: Execution on the 14th day

    The Rated Perceived Exertion was measured during the treadmill exercise by Bruce Protocol, a gradual increase in the speed and the slope of the treadmill every 3 minutes.

  3. blood lactate

    Time frame: Execution on the 14th day

    fingertip capillary blood was placed in automated blood lactate analyzer

  4. Continuous attention performance test

    Time frame: Execution on the 14th day

    10 minutes after maximal exercise test, the subjects performed attention tests that used Canon continuous attention software

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Official study title

The Anti-fatigue Effect of Gojinsen® Drink

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Nov 22, 2021
Registry last updated
Dec 6, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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