Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
Location status: Recruiting
Recruiting
NCT Number: NCT06091904
Effects of Sufentanil on the Intraoperative Hemodynamics
This study is a randomized, controlled trial. A total of 92 patients will be randomized to receive sufentanil or remifentanil during extracranial-intracranial bypass surgery.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
19 year and older
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Patients who undergo elective extracranial-intracranial bypass surgery
- American Society of Anesthesiologists grade 1,2,3
- Age > 18 years old
Exclusion criteria
- Refuse to participate to the study
- American Society of Anesthesiologists grade 4
- Body Mass Index < 18.5 kg/m2 or > 35 kg/m2
- Allergic history of opioid
- pregnant
- MAO Inhibitor user
- Severe respiratory insufficiency
Treatment and study plan
Sufentanil
DrugInduction: sufentanil TCI 0.3 ng/ml Maintenance: sufentanil TCI 0.05-0.5 ng/ml
Remifentanil
DrugInduction: remifentanil TCI 3 ng/ml Maintenance: remifentanil TCI 0.5-5 ng/ml
Primary outcomes
-
Intraoperative hypotension
Time frame: During surgery
MAP < 80 mmHg
Secondary outcomes
-
Inotropic requirements
Time frame: During surgery
cumulative doses of inotropics during surgery
-
Incidence of bradycardia
Time frame: During surgery
heart rate < 40/min
-
Incidence of tachycardia
Time frame: During surgery
heart rate > 100/min
-
Maximum systolic blood pressure
Time frame: During surgery
maximal systolic blood pressure
-
Minimum systolic blood pressure
Time frame: During surgery
minimal systolic blood pressure
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Seoul National University Hospital
Other
Registry information
Official study title
Effects of Sufentanil on the Intraoperative Hemodynamic Parameters in Patients Undergoing Extracranial-intracranial Bypass Surgery: a Prospective Randomized Controlled Trial
Important dates
- Study start
- 2023
- Primary completion
- 2025
- Study completion
- 2026
- First posted
- Oct 19, 2023
- Registry last updated
- Sep 16, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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