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OpenTrials
Completed

NCT Number: NCT00000251

Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide - 3

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. To evaluate the acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations in healthy volunteers.

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Key information

Conditions

Opioid-related Disorders Chemically-Induced Disorders Mental Disorders Narcotic-Related Disorders Substance-Related Disorders

Age range

21 year–32 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Chicago, Anesthesia & Critical Care

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Please contact site for information.

Treatment and study plan

30% N2O

Drug

0.2% isoflurane

Drug

0.4% isoflurane

Drug

100% Oxygen

Other

Placebo

Primary outcomes

  1. Logical reasoning test

    Time frame: 15 & 30 min inhalation and 5, 30, & 60 min post inhalation

  2. Free recall memory test

    Time frame: 15 & 30 min inhalation and 5, 30, & 60 min post inhalation

  3. Auditory reaction time

    Time frame: 15 & 30 min inhalation and 5,30 & 60 min post inhalation

  4. Digit symbol substitution test

    Time frame: 2,15 & 30 min inhalation and 5,30 & 60 min post inhalation

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide

Important dates

Study start
1994
Primary completion
1996
Study completion
1996
First posted
Sep 21, 1999
Registry last updated
Dec 2, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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