Skip to main content
OpenTrials
Completed

NCT Number: NCT04146740

Effects of Structured Exercise Regime in Gestational Diabetes Mellitus

Rehabilitation in the field of Obstetrics is an emerging field worldwide although it is still very much neglected in a country like Pakistan. Increasing prevalence of GDM has highlighted the importance of rehabilitation in this specific area. In USA upto14% of pregnancies get GDM problem, 6.8 to 10.4 % in China while in India 27.5% which is exceptionally high. Similarly in Pakistan it has become a common issue.

Many observational studies have been done to find the risk factors and causes of GDM. However to the best of investigator's knowledge no experimental study have been done so far on the effects of exercise on physical, physiological and psychological aspects of GDM. Hence a randomized control trial is planned on diagnosed GDM patients in Fauji Foundation Hospital Rawalpindi who will recieve supervised structured exercise regeme for 5 weeks and their data will be recorded using reliable tools at the baseline and after 5 weeks to assess the effects of exercise.

Completed

Looking for future studies?

Notify Me

Key information

Age range

20 year–40 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Foundation University Islamabad

Islamabad, Federal, 45710, Pakistan

About this study

GDM is a medical condition of high maternal glucose level which is diagnosed only when women are pregnant and overcome after pregnancy. It results in various maternal and neonatal complications like caeserean delivery in mothers and obesity in children. Women having GDM have greater risk of diabetes and cardiovascular problems later in life which is threatening for us. Obese women are at increased risk of developing GDM and it is also a risk factor for developing high blood pressure and protein in the urine after 20 weeks of pregnancy that condition is known as preeclampsia.

Many studies have shown that physically active women are less prone to develop GDM as compare to those women who have sedentary life style which draws attention towards the role of antenatal exercises for prevention and management of GDM and has become the first line treatment in developed countries. In addition to obesity and sedentary life style other known risk factors are family history, age of mother and number of children but there is no definite single cause of GDM yet discovered.

Exercises programs during pregnancy are not usually practiced in our population and routine domestic activities are considered as enough for fitness. We have a common myth that pregnant women should not do treadmill or stationary cycle or any other aerobic activity which is really wrong and resulting in problems like GDM. Women following moderate exercise programs during their pregnancy have reported reduction in daily insulin administration dosage in comparison with women not doing any prescribed exercise. As Gestational weight gain is a major risk factor for GDM, exercises have given evidence to facilitate weight reduction.

Exercise programs prescribed by physical therapists during pregnancy for preventing and managing GDM are considered useful and recommended by researchers and practitioners around the world but in developing countries like Pakistan, women are not receiving this method of treatment due to lack of awareness in general public, lack of referral system from gynaecologists and obstetricians and unavailability of women health Physical therapists in hospital set ups.

This study will provide data showing the effects of exercise in biomarkers level and give the option of treatment to obstetricians.

This will fill the research gap in the area of rehabilitation in GDM. This will also highlight the importance of women health physical therapists in obstetric conditions as there is less awareness of this speciality in Pakistan.

This will provide the data regarding which type, intensity and duration of exercise should be recommendable while treating GDM.

This study will open new doors for researchers to do long term studies on different biomarkers with different exercise types.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women with age of 20 to 40 years and gestational age more than 20 weeks.
  • Diagnosed Gestational diabetes mellitus patients
  • Must be able to do 6 min walk test and lie under severity level 6 on the 0-10 Borg scale of breathlessness -

Exclusion criteria

  • Diagnosed neurological and cardiopulmonary problems.

-

Treatment and study plan

Structured Exercise for Experimental (Structured Exercise) Group

Other

Structured aerobic exercise regime of moderate intensity by using stationary cycle (3-5 MET) 10 min, brisk walk 10 min.

The combination of Stabilization exercise (10 repeatitions) and PFM training ( 20 repeatitions set).

Relaxation therapy including Mitchells physiological relaxation technique (10 repetitions) along with deep breathing exercises.

Control treatment for both groups

Behavioral

Medical and dietary interventions like insulin in addition of the postural education and back care from Physical Therapist.

Primary outcomes

  1. HbA1c

    Time frame: 5 weeks

    HbA1c will be assessed at the base line and at the end of 5 weeks session. Lower score shows better outcome.

  2. Blood Pressure

    Time frame: 5 weeks

    Change in the Values of Blood pressure will be assessed at base line and at the end of 5 weeks session.

  3. Lipid profile

    Time frame: 5 weeks

    Lipid profile will be assessed at the base line and at the end of 5 weeks session

  4. Renal function test (RFT)

    Time frame: 5 weeks

    RFT will be assessed at the base line and at the end of 5 weeks session. Lower score shows better outcome.

  5. C reactive protein

    Time frame: 5 weeks

    C reactive protein will be assessed at the base line and at the end of 5 weeks session. Lower score shows better outcome.

  6. Heart rate

    Time frame: 5 weeks

    Change in the heart rate will be assessed at base line and at the end of 5 weeks session.

  7. Respiratory rate

    Time frame: 5 weeks

    Change in the respiratory rate will be assessed at base line and at the end of 5 weeks.

  8. Blood glucose level

    Time frame: 5 weeks

    Change in the blood glucose level will be assessed at base line and at the end of 5 weeks session.

Secondary outcomes

  1. Gestational weight gain

    Time frame: 5 weeks

    Gestational weight gain by recording weight of women in pounds and gestational age in weeks at baseline and then after 5 weeks.

  2. Edinburgh Post Natal Depression scale (Punjabi version)

    Time frame: 5 weeks

    The score of Depression using Edinburgh Post Natal Depression scale (Punjabi version). Each answer is given on a score of 0-3 . Maximum score is 30 A score of 10 or higher indicates that depressive symptoms have been

Sponsors and collaborators

Lead sponsor

Foundation University Islamabad

Other

Registry information

Official study title

Effects of Structured Exercise Regime for the Management of Gestational Diabetes Mellitus (GDM) - Bio Psychosocial Perspectives.

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Oct 31, 2019
Registry last updated
Aug 31, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.