Effects of Spinal vs General Anesthesia on Systemic Inflammation in PCNL

This observational study aims to compare the effects of spinal and general anesthesia on perioperative systemic inflammatory response in patients undergoing percutaneous nephrolithotomy (PCNL). Systemic inflammatory indices derived from routine complete blood count parameters, including Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW), will be evaluated. Preoperative and postoperative laboratory values will be analyzed to determine whether the type of anesthesia influences systemic inflammatory markers and related clinical outcomes.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Anesthesia Techniques Percutaneous Nephrolithotomy Systemic Inflammation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fethi Sekin City Hospital

Elâzığ, Elaziğ, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

American Society of Anesthesiologists (ASA) physical status class I-III
Patients aged 18 years and older

Exclusion criteria

American Society of Anesthesiologists (ASA) physical status class IV or V
Patients younger than 18 years
Active infection or diagnosis of sepsis
Malignancy
Chronic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)
Use of immunosuppressive therapy
Pregnancy

Treatment and study plan

Primary outcomes

Perioperative change in systemic inflammatory indices (SII, SIRI, AISI, NLR, RDW)

Time frame: From preoperative period (within 6 hours before surgery) to postoperative period (6-24 hours after surgery)

Changes in Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), Neutrophil-to-Lymphocyte Ratio (NLR), and Red Cell Distribution Width (RDW) will be evaluated using routine complete blood count parameters obtained preoperatively and postoperatively.

Sponsors and collaborators

Lead sponsor

Elazıg Fethi Sekin Sehir Hastanesi

Other

Registry information

Official study title

Comparison of Spinal and General Anesthesia on Systemic Inflammatory Response in Patients Undergoing Percutaneous Nephrolithotomy: Evaluation of SII, SIRI, AISI, NLR, and RDW

Acronym: PCNL-ANES-INF

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jan 8, 2026
Registry last updated: Jun 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed