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OpenTrials
Completed

NCT Number: NCT00457262

Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women

paraoxonase 1 is involved to prevent LDL and HDL oxidation,so increase of it's activity leads to lower risk of coronary heart disease.In postmenopausal women ,we have decrease of paraoxonase1 activity and soy proteins may increase paraoxonase1 activity

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Key information

Conditions

Postmenopausal Dyslipidemias Hyperlipidemia Hyperlipidemias Lipid Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

51 year–57 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

About this study

In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cessation of menes for more than 1 year, elevation for more than 1 year
  • Elevation of FSH level
  • Total cholesterol
  • Triglyceride more than 200 mg/dl

Exclusion criteria

  • Chronic disease (heart disease, cancer, diabetes, hepatic, kidney and thyroid disease)
  • Antihypertensive drugs
  • Antibiotics
  • Lipid lowering drugs
  • Sex hormone treatment
  • Hysterectomy
  • Diet rich in soy protein

Treatment and study plan

soy consumption

Procedure

Primary outcomes

  1. decrease of LDL,increase of HDL,increase of paraoxonase 1

Sponsors and collaborators

Lead sponsor

Iran University of Medical Sciences

Other

Registry information

Important dates

Study start
2006
Study completion
2006
First posted
Apr 6, 2007
Registry last updated
Apr 6, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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