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OpenTrials
Completed

NCT Number: NCT04826276

Effects of Smoking State on Decision Making

Adult smokers will be tested using behavioral and neuroimaging measures after smoking as usual and after overnight abstinence.

Completed

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Key information

Conditions

Behavior

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wake Forest University School of Medicine

Winston-Salem, North Carolina, 27101, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18-55 years
  • Smokes cigarettes or e-cigarettes
  • Negative urine drug screen

Exclusion criteria

  • Unstable or serious medical or mental health condition
  • History of serious head trauma
  • Pregnancy
  • Unsuitable for MRI
  • Weight > 350 pounds (maximum allowed for MRI)

Treatment and study plan

smoking abstinence

Other

participants will be asked to not smoke for at least 12 hours

smoking satiety

Other

participants will be asked to smoke as usual

Primary outcomes

  1. Effort Based Decision Making

    Time frame: approximately 2 weeks

    number of high effort selections

  2. Distress Tolerance Behavior

    Time frame: approximately 2 weeks

    duration on measures of distress tolerance

Sponsors and collaborators

Lead sponsor

Wake Forest University Health Sciences

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Effects of Smoking State on Effort-based Decision Making

Acronym: Effort

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Apr 1, 2021
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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