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NCT Number: NCT07061522

Effects of Smoking Addiction on Lower Limb Speed and Coordination

This observational case-control study will investigate the impact of smoking addiction on lower extremity speed and coordination in young adults. Participants aged 18-25 will be divided into two groups based on their smoking status. The study will compare motor coordination and sprint performance between smokers and non-smokers using objective physical tests under standardized laboratory conditions.

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Key information

Age range

18 year–25 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Esra Pehlivan

Istanbul, Üsküdar, 34668, Turkey (Türkiye)

Location status: Recruiting

Location contact

ESRA PEHLİVAN

CONTACT

[email protected]

02164189616

About this study

This non-randomized controlled study will aim to evaluate the effects of smoking addiction on the speed and coordination of lower extremity movements among healthy young adults. Smoking is known to have detrimental effects on vascular, musculoskeletal, and neurological systems, yet its impact on motor performance-particularly in the lower limbs-has not been sufficiently studied.

Participants aged 18-25 will be categorized into smoker and non-smoker groups based on DSM-IV-TR nicotine dependence criteria and the Fagerström Test. The Lower Extremity Motor Coordination Test (LEMOCOT) will be used to assess motor coordination, while a 30-meter sprint test will evaluate movement speed. Additionally, body mass index (BMI) and bimalleolar diameter and circumference will be recorded to control for confounding physical variables.

All assessments will be conducted in a controlled laboratory environment. The results will be analyzed to determine whether smoking addiction is associated with impaired lower limb motor function. The findings may provide new insights into the functional consequences of smoking in young adults and contribute to the design of preventive and rehabilitative strategies.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Smoking ≥1 cigarette daily for at least 12 months
  • Age between 18-25
  • Literate and cooperative
  • BMI: 18.5-29.9 kg/m²

Exclusion criteria

  • Orthopedic, neurological, or neuromuscular conditions impairing walking
  • Chronic pulmonary or cardiac disease
  • Cognitive impairment
  • BMI ≥30 kg/m²

Treatment and study plan

Behavioral/Physical Assessment

Other

This study will not include any therapeutic or clinical intervention. Instead, participants will undergo a series of structured physical and questionnaire-based assessments to evaluate lower extremity motor performance. These include the Fagerström Test for Nicotine Dependence and DSM-IV-TR criteria to classify smoking addiction. Anthropometric measurements such as Body Mass Index (BMI) and bimalleolar diameter/circumference will be recorded to assess potential confounding structural factors. Lower extremity coordination will be evaluated using the Lower Extremity Motor Coordination Test (LEMOCOT), and movement speed will be assessed with a 30-meter sprint test. All assessments will be conducted once in a controlled laboratory setting and are intended solely for comparative analysis between smokers and non-smokers.

Primary outcomes

  1. Lower Extremity Coordination Score

    Time frame: Baseline

    Tool: LEMOCOT (Lower Extremity Motor Coordination Test) Description: Total number of valid taps within 20 seconds.

  2. Sprint Time

    Time frame: Baseline

    Tool: 30-Meter Sprint Test Description: Time in seconds taken to complete a 30-meter run at maximum speed.

Secondary outcomes

  1. Nicotine Dependence Score

    Time frame: Baseline

    Tool: Fagerström Test for Nicotine Dependence Description: Total score assessing severity of nicotine addiction.

  2. BMI (Body Mass Index)

    Time frame: Baseline

    Calculated as weight (kg)/height² (m²), to assess weight-related influence on movement.

  3. Bimalleolar Diameter and Circumference

    Time frame: Baseline

    Measured with caliper and tape to assess potential structural differences affecting motor coordination.

Study contacts

Contact information is provided by the study sponsor or research team.

Edanur Kocakaplan

CONTACT

[email protected]

Esra Pehlivan, Associate Professor

CONTACT

[email protected]

+90216 777 87 77

Sponsors and collaborators

Lead sponsor

Saglik Bilimleri Universitesi

Other

Registry information

Official study title

Investigation of the Impact of Smoking Addiction on the Speed and Coordination of Lower Extremity Movements

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jul 11, 2025
Registry last updated
Aug 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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