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NCT Number: NCT07536503

Effects of Sleep Quality on Functional and Cognitive Outcomes in Multiple Sclerosis

The goal of this observational study is to investigate the effects of sleep quality on cognitive flexibility, physical activity level, body awareness, and reaction time in individuals with Multiple Sclerosis.

The main question it aims to answer is:

Does sleep quality influence cognitive flexibility, physical activity level, body awareness, and reaction time in individuals with Multiple Sclerosis?

Researchers will compare individuals with good and poor sleep quality to determine whether differences in sleep quality result in variations in cognitive and physical performance outcomes.

Participants will complete standardized assessments of sleep quality, cognitive flexibility, physical activity, and body awareness, and will perform a computer-based reaction time test. In addition, participants will wear a wearable activity tracker for 7 days to objectively measure physical activity levels.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Behavior Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Dyssomnias Immune System Diseases Mental Disorders Motor Activity Nervous System Diseases Sleep Disorders, Intrinsic Sleep Initiation and Maintenance Disorders Sleep Wake Disorders

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Baskent University Ankara Hospital

Ankara, 06810, Turkey (Türkiye)

Location status: Recruiting

Location contact

Süleyman Korkusuz, PhD

CONTACT

[email protected]

+905388675480

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 65 years
  • Diagnosis of Multiple Sclerosis
  • Montreal Cognitive Assessment (MoCA) score ≥24
  • Expanded Disability Status Scale (EDSS) score between 0 and 6.5
  • No relapse within the last 3 months
  • Voluntary participation with written informed consent

Exclusion criteria

  • Presence of other neurological, psychiatric, or systemic diseases
  • Severe visual, auditory, or balance impairments
  • History of surgery within the last 6 months
  • Use of sleep medication or central nervous system-affecting drugs
  • Severe orthopedic deformity or pain

Treatment and study plan

Primary outcomes

  1. Sleep Quality (Pittsburgh Sleep Quality Index)

    Time frame: Baseline

    Sleep quality will be assessed using the Pittsburgh Sleep Quality Index. Total scores range from 0 to 21, with higher scores indicating poorer sleep quality.

  2. Cognitive Flexibility (Stroop Test, TBAG Form)

    Time frame: Baseline

    Cognitive flexibility will be evaluated using the Stroop Test TBAG Form. Test completion time and number of errors will be recorded; longer completion times and more errors indicate lower cognitive flexibility.

  3. Physical Activity Level (International Physical Activity Questionnaire-Short Form)

    Time frame: Baseline

    Physical activity level will be assessed using the International Physical Activity Questionnaire-Short Form. Total physical activity will be calculated in MET-min/week.

  4. Physical Activity Level (Wearable Device)

    Time frame: 7 days

    Daily step count will be recorded using a wearable activity tracker. Average step count over 7 days will be calculated.

  5. Body Awareness Questionnaire

    Time frame: Baseline

    Body awareness will be evaluated using the Body Awareness Questionnaire. Higher scores indicate greater body awareness.

  6. Reaction Time (computer-based reaction time test)

    Time frame: Baseline

    Reaction time will be assessed using a computer-based reaction time system. Average response time to visual stimuli will be recorded, with shorter times indicating better reaction performance.

Study contacts

Contact information is provided by the study sponsor or research team.

Süleyman Korkusuz, PhD

CONTACT

[email protected]

+905388675480

Sponsors and collaborators

Lead sponsor

Büşra Seçkinoğulları Korkusuz

Other

Collaborators

  • Atılım University
  • Baskent University Ankara Hospital

Registry information

Official study title

Effects of Sleep Quality on Cognitive Flexibility, Physical Activity, Body Awareness, and Reaction Time in Multiple Sclerosis

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 17, 2026
Registry last updated
Jun 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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