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NCT Number: NCT07304479

Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery

Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.

Recruiting

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Key information

Conditions

Respiratory Mechanics Intraoperative

Age range

18 year–87 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 to 87 years
  • Undergoing elective robotic-assisted abdominal surgery
  • ASA physical status I-III

Exclusion criteria

  • ASA IV or V
  • Emergency surgery
  • Renal insufficiency
  • Clinically significant respiratory disease
  • Cardiomyopathy
  • Uncontrolled hypertension

Treatment and study plan

Sevoflurane (Volatile Anesthetic)

Drug

Sevoflurane for robotic assisted laparoscopic surgery

Desflurane (volatile anesthetic)

Drug

Desflurane for robotic assisted laparoscopic surgery

Primary outcomes

  1. airway plateau pressure

    Time frame: Perioperatively

    Airway plateau pressure (cmH2O) as displayed on the anesthesia ventilator at the specified time points will be recorded for each participant.

Study contacts

Contact information is provided by the study sponsor or research team.

Aliki Tympa, MD,PhD

CONTACT

[email protected]

00306955487575

Sponsors and collaborators

Lead sponsor

National and Kapodistrian University of Athens

Other

Registry information

Official study title

Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 26, 2025
Registry last updated
Dec 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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