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OpenTrials
Completed

NCT Number: NCT00700596

Effects of Salvinorin A in Healthy Controls

This study evaluates the effects of Salvinorin A (SA). SA is the active ingredient of the plant Salvia divinorum that is known to have been used by Mexican Indians as part of religious rituals. The purpose of this project is to understand what people experience when they consume Salvinorin A.

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Key information

Conditions

Healthy

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

VA Connecticut Healthcare System

West Haven, Connecticut, 06516, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-Previous exposure to inhaled Salvinorin A (SA).

Treatment and study plan

Salvinorin A

Drug

Low dose: Active SA 250μg Medium Dose: Active SA 500μg High Dose: Active SA 750μg

Other names: SA, Salvia, Salvia Divinorim

Placebo

Drug

Control or Placebo SA (30 % ethanolic solution)

Primary outcomes

  1. Positive and Negative Syndrome Scale, Clinician Administered Dissociative Symptoms Scale, Visual Analog Scale, Assessment of Opioid Effects, Cognitive Testing

    Time frame: Time Frame: -30, +10, +30, +90, +120. +200

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Alliance for Research on Schizophrenia and Depression

Registry information

Official study title

Psychotomimetic Effects of Kappa Opioid Receptor Agonist Salvinorin A in Healthy Controls

Important dates

Study start
2009
Primary completion
2014
Study completion
2014
First posted
Jun 18, 2008
Registry last updated
Apr 7, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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