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Completed

NCT Number: NCT04804657

Effects of Sage Extracts on Cognitive Function During Aerobic Exercise

Extracts of sage have been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has clearly demonstrated the possible effects in healthy individuals in fatiguing conditions. The current study investigates the effects of this supplementation in healthy males and females versus placebo on cognition, heart rate and perceived exertion, during a fatiguing cycling exercise.

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Key information

Conditions

Healthy Fatigue Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre d'Expertise de la Performance

Dijon, 21000, France

About this study

Healthy males and females will be tested in fresh and fatiguing conditions to mimic individuals at the beginning or during a competition where cognitive function are important for decision making for example. Tests will be conducted during the warm-up (fresh), during fatiguing situations (during two consecutive 10-minutes pedaling exercises) and during recovery. Tests will include a reverse digit memory test (from 3 to 7 digits), a stroop test, a simple reaction time test. Moreover, heart rate and rating of perceived exertion will be quantified.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Body mass index lower than 27 and waist size lower than 94 cm
  • physical activity higher than 3 hours a week
  • written informed consent

Exclusion criteria

  • more than 12 hours training a week
  • asthmatic, smokers or under medicinal drugs
  • dietary supplement, sports drink, special dietary food or functional food, of any kind, liable or presented as liable to enhance physical performances

Treatment and study plan

Sage extracts Cognivia

Dietary Supplement

Cognivia is composed of 400 mg of aqueous extract from Salvia officinalis and the remaining 200 mg contained 50 µL of Salvia lavandulaefolia essential oil and encapsulated with gum acacia. It will be administrated the the morning before the endurance test (oral administration).

Placebo

Dietary Supplement

Made with maltodextrin. It will be administrated the the morning before the endurance test (oral administration).

Primary outcomes

  1. Memory

    Time frame: During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period

    Changes in percent number of correct answers during a reverse digit immediate memory test

Secondary outcomes

  1. Heart rate

    Time frame: At rest, at the end of the 10-minutes warm-up, at the end of the first 10-minutes fatiguing exercise, at the end of the second 10-minutes fatiguing exercise, after 5 minutes of recovery

    Changes in heart rate using a polar belt (in beats per minutes)

  2. Rating of perceived exertion

    Time frame: At rest, at the end of the 10-minutes warm-up, at the end of the first 10-minutes fatiguing exercise, at the end of the second 10-minutes fatiguing exercise, after 5 minutes of recovery

    Changes in rating of perceived exertion using a visual analogic scale (1-10)

  3. Reaction time

    Time frame: During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period

    Changes in reaction time between a visual signal and manual action

  4. Stroop performance

    Time frame: During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period

    Changes in percent number of correct answers during a stroop test

  5. Stroop reaction time

    Time frame: During the 10-minutes warm-up, immediately after the first 10-minutes fatiguing exercise, after the second 10-minutes fatiguing exercise and after a five minutes recovery period

    Changes in reaction time during the stroop test

Sponsors and collaborators

Lead sponsor

University of Burgundy

Other

Registry information

Official study title

Effects of Sage Extracts on Cognitive Function During Aerobic Exercise in Healthy Individuals

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Mar 18, 2021
Registry last updated
Mar 18, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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