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NCT Number: NCT07563114

Effects of Rosemary Essential Oil on Human Cognition

Aromatherapy is one of the complementary therapies that is carried out through essential oils. The essential oil of Rosmarinus Officinalis L. (rosemary) has been gaining attention in aromatherapy research, as studies have shown that the use of this oil is one of the promising non-pharmacological therapies for cognition. In this way, inhalation of rosemary essential oil is one of the forms of cognitive intervention across different age groups. The study will aim to analyze the effect of rosemary essential oil, with the following chemotypes: camphor and cineole, on the cognitive performance of adults. Significant differences are expected between the control (placebo) and experimental groups, given that studies in humans have already shown significant effects of rosemary essential oil on cognition. Considering the inclusion and exclusion criteria of the study, participants will be allocated to either the control or experimental group. Consequently, the application of the tests will be carried out neuropsychological tests for the pre-test evaluation, followed by aromatherapy (acute phase) and the reapplication of the tests (post-test phase 1). For 14 days, the participants will chronically use rosemary essential oil and at the end they will participate in the reapplication of the neuropsychological tests (post-test phase 2). For inferential analyses, the ANOVA test or its non-parametric equivalent will be used. In addition, linear regressions may be performed to verify how much the essential oil can predict the outcome of the study's dependent variables. Effect Size will also be calculated. Keywords: Chronic intervention; neuropsychology; aromatherapy.

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Key information

Conditions

Aromatherapy Cognition

Age range

18 year–59 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Helô

João Pessoa, Paraíba, 58062-106, Brazil

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

  • Inclusion Criteria:
  • 1a Healthy adults
  • 1b should be able to inhale the essential oil
  • Exclusion Criteria:
  • 2a Neurodegenerative diseases
  • 2b Traumatic brain injury
  • 2c Brain tumors
  • 2d Multiple sclerosis
  • 2e Epileptic seizures
  • 2f Anxiety Disorder
  • 2g Depressive Disorders,
  • 2h Uncontrolled arterial hypertension,
  • 2i nutritional deficiency or thyroid disease.

Treatment and study plan

rosemary1

Other

oil essential

Primary outcomes

  1. STROOP TEST

    Time frame: Cognitive tests were administered at the following stages: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

    Unit of measurement: time (seconds)

  2. Subteste Digits of the Test WAIS-III - (Wechsler Adult Scale)

    Time frame: Cognitive tests were administered at the following stages: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

    1a. Maximum raw score: 30

    1b. Minimum raw score: 2

  3. Subtest Number and Letter Sequence of the WAIS-III Test - (Wechsler Adult Scale)

    Time frame: Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

    1.0 Measurement Units: raw score 1a. Maximum raw score: 21

    1b. Minimum raw score: 0

  4. Tower of London

    Time frame: Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

    1.0 Measurement Units: raw score 1a. Maximum raw score: 46

    1b. Minimum raw score: 0

  5. Token Test

    Time frame: Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

    1.0 Measurement Units: raw score 1a. Maximum raw score: 36

    1b. Minimum raw score: 0

  6. Corsi Blocks

    Time frame: Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

    1.0 Measurement Units: raw score 1a. Maximum raw score: 30

    1b. Minimum raw score: 0

  7. Hopkins Verbal Learning

    Time frame: Cognitive test were administered at the following times: "Before the intervention (baseline), immediately after the intervention, and 1 week after the intervention."

    1.0 Measurement Units: raw score 1a. Maximum raw score: 0

    1b. Minimum raw score: 36

Sponsors and collaborators

Lead sponsor

Federal University of Paraíba

Other

Registry information

Official study title

The Use of Rosmarinus Officinalis L. Essential Oil (Camphor and Cineol Chemotypes) in Cognition: a Randomized, Double-blind, Placebo-controlled Study

Acronym: Rosmarinus

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 1, 2026
Registry last updated
May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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