Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults

To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.

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Key information

Conditions

Healthy Aging Healthy Diet

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Zurich, Canton of Zurich, 8057, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥18 years
Healthy
Non-smoking
Body mass index (BMI): 18.5 - 29.9 kg∙m-2
Normal lung function
Willing to adhere to study rules

Exclusion criteria

Known or suspected non-compliance, drug or alcohol abuse
Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
Previous enrolment into the current study
Intake of medications affecting metabolism, the cardiovascular or the respiratory system, or sleep
Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
Pregnancy, breastfeeding, or intention to become pregnant during the study

Treatment and study plan

5min respiratory muscle exercises

Other

5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose

15min respiratory muscle exercises

Other

5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose

Primary outcomes

Peak blood glucose concentration

Time frame: throughout the study, an expected average of 2 weeks per participant

Peak blood glucose concentration will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).
area under the glucose-time curve

Time frame: throughout the study, an expected average of 2 weeks per participant

Area under the glucose-time curve will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).

Sponsors and collaborators

Lead sponsor

Swiss Federal Institute of Technology

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Aug 20, 2020
Registry last updated: Mar 17, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed